摘要
目的观察玻璃体内注射康柏西普对渗出性老年性黄斑变性(age-related macular degeneration,AMD)患者脉络膜厚度(choroidal thickness,CT)的影响。方法确诊为渗出性AMD患者42例42眼,分为典型AMD(typical-AMD,t AMD)组和息肉样血管病变(polypoidal choroidal vasculopathy,PCV)组,均行3+PRN方案的玻璃体内注射康柏西普治疗。采用光学相干断层扫描的增强深度成像技术测量治疗前及初次治疗后1个月、2个月、3个月、6个月治疗眼及对侧眼中心凹下脉络膜厚度(subfoveal choroidal thickness,SFCT)及距离中心凹1 mm的鼻侧和颞侧CT,对比分析康柏西普治疗前后的CT变化。结果渗出性AMD患眼玻璃体内注射康柏西普后1个月、2个月、3个月、6个月SFCT分别为(223.55±30.71)μm、(221.52±33.37)μm、(214.43±31.81)μm、(214.93±31.41)μm;治疗后6个月鼻侧CT从(225.40±43.97)μm减少至(205.71±42.20)μm,颞侧CT从(235.21±47.22)μm降至(203.52±39.15)μm;与基线相比,差异均具有统计学意义(均为P<0.001)。其中,t AMD组SFCT从(234.06±41.04)μm减至(209.19±32.14)μm,PCV组从(274.60±27.73)μm减至(233.30±21.08)μm,各随访时间点所测SFCT与基线时相比差异均具有统计学意义(均为P<0.05),而对侧正常眼6个月各时间点SFCT无明显改变。结论玻璃体内注射康柏西普会引起渗出型AMD(t AMD和PCV)CT降低。
Objective To observe the effects of intravitreal conbercept injections on choroidal thickness （CT） in exudative age-related macular degeneration （ AMD ）. Methods Forty-two patients （42 eyes） with exudative AMD who received 3 ＋ PRN intravitreal conbercept injection treatment over a 6-month period were divided into two groups： tipical AMD （ t-AMD ） group and polypoidal choroidal vasculopathy （ PCV ） group. High-definition optical coherence tomography with enhanced depth imaging mode was used to measure the subfoveal choroidal thickness （SFCT）, nasal and tempo- ral 1 mm near to the center of the fovea of the affected eyes and the fellow eyes before and after the treatment at l month, 2 months. 3 months and 6 months. The changes of CT before and after use of conbercept was compared. Results Of all the patients, subfoveal choroidal thickness at 1 month,2 months ,3 months and 6 months after injection were （223.55 ±30.71 ） μm, （221.52 ± 33.37） μm, （214.43 ± 31.81 ） μm, （214.93 ± 31.41 ） μm,respectively;Nasal CT decreased from（225.40 ± 43.93 ） μm to （205.71 ± 42.20） μm and temporal CT decreased from（235.21 ±47.22）μm to （203.52 ±39.15）μm,and there were statistical significant differences compared with baseline （all P 〈 0. 001 ）. SFCT of typieal-AMD eyes decreased from （234.06 ± 41.04 ） μm to （209.19 ± 32.14 ） μm, while the PCV eyes reduced from（274.60 ± 27.73 ） μm to （ 233.3 ± 21.08 ） μm, and there were statistical significant differ- ences compared with baseline （ all P 〈 0.05 ）. SFCT variations of the fellow eyes showed no statistical significant differences. Conclusion A significant reduction in CT is noted after intravitreal conbercept injections in exudative AMD.
出处
《眼科新进展》
CAS
北大核心
2016年第12期1172-1175,共4页
Recent Advances in Ophthalmology
关键词
老年性黄斑变性
脉络膜厚度
光学相干断层扫描
康柏西普
age-related macular degeneration
choroidal thickness
optical coher-ence tomography
conbercept
