摘要
目的研究丙氨酰谷氨酰胺对重症脓毒症患者的营养状况及免疫功能的影响。方法以2012年8月—2015年10月,清远市人民医院ICU收治的160脓毒症患者为研究对象,随机将患者分为2组,试验组在常规治疗的基础上添加0.4 g/kg·d(最大剂量20 g)的丙氨酰谷氨酰胺静脉滴注,对照组仅采用常规治疗。分析比较两组患者的血清前白蛋白(PA)、白蛋白(ALB)、转铁蛋白(TF)等反映营养状况指标,及Ig G、Ig M、Ig A、C3、C4等反映免疫功能指标。结果试验组与对照组比较血清前白蛋白、转铁蛋白显著提高(P<0.05),Ig G、C3、C4亦显著提高(P<0.05)。结论每日静脉滴注丙氨酰谷氨酰胺最大量可能有助于改善脓毒症患者的营养状况及免疫功能。
Objective To access the effect of added alanyl glutamine on nutritional condition and immunological function in patients with severe sepsis. Methods Between August 2012 and October 2015,the 160 septic patients who were assigned in the intensive care unit of Qingyuan hospital were randomized into two groups;trial group received added alanyl glutamine with a dosage as 0.4 g/kg·d（upper volume 20 g/d）,control group received all the routine treatment of sepsis except alanyl glutamine. Prealbumin（PA）,albumin（ALB） and transferrin（TF） were accessed as the measurement of nutritional condition;Ig G,Ig M,Ig A,C3 and C4 were accessed as the measurement of immunological function. Results Compared with the control group,the patients in the trial group had significantly higher level of PA,TF（P〈0.05）,and Ig G,C3,C4（P〈0.05）. Conclusion For the patients with severe sepsis,the daily intravenously maximum dose of alanyl glutamine may help to improve their nutritional condition and immunological function.
出处
《实用医药杂志》
2016年第11期971-972,976,共3页
Practical Journal of Medicine & Pharmacy
基金
清远市科技计划项目(00116561320527018)
关键词
丙氨酰谷氨酰胺
脓毒症
营养状况
免疫功能
Alanyl glutamine
Sepsis
Nutritional condition
Immunological function
