摘要
该文系统性地回顾分析了人类无绿藻病在近10a来的发病率及其趋势,并对该病的流行病学、临床表现、诊断标准、治疗方案及其预后的新特点进行了总结。全球至今已报道190例无绿藻病,约33%的无绿藻病例在近10a内发生;系统性无绿藻发病率在近10a病例数与皮肤型无绿藻病基本持平。我国大陆地区总共报道有9例无绿藻病,大约占我国(包括港澳台地区)已有报道的无绿藻病例总数的50%。无绿藻病的诊断主要依靠标本的真菌学及组织病理学检查。两性霉素B及其脂质体仍然是该病治疗最常用且最有效的药物。提示无绿藻病在近10a中发病率明显上升,且系统性无绿藻发病率显著升高。
We systematically review all the published cases in the last decade to realize the newest incidence and trends of protothecosis and comprehensively analyze the new character of protothecosis in epidemiology,clinical manifestations,therapy and prognosis.The amount of protothecosis cases since the first case had been reported was 190,and nearly 33% of the cases were reported in last decade.In recent years,the cases of disseminated protothecosis almost equals cutaneous protothcosis.In last decade,9cases had been reported in mainland which conclude half of total number of protothcosis in China.The diagnose of protothecosis still relied on mycology and histopathology examination.Amphotericin B and its liposome were still the most commonly used and effective antifungal to cure protothcosis.These showed the rising incidence of protothcosis or disseminated protothecosis worldwide.
出处
《中国真菌学杂志》
CSCD
2016年第5期310-315,共6页
Chinese Journal of Mycology
基金
国家自然科学基金(81573056)
关键词
无绿藻病
中型无绿藻
小型无绿藻
Protothecosis
Prototheca zopfii
Prototheca wickerhamii
