摘要
目的:探讨2型糖尿病(type 2 diabetes mellitus,T2DM)患者血浆成纤维细胞生长因子-21(fibroblast growth factor 21,FGF-21)水平变化以及观察短期胰岛素强化治疗对FGF-21水平的影响。方法:选择我院2013年1月至2015年1月收治的T2DM患者64例,其中初诊T2DM患者32例(T2DM组),T2DM合并大血管病变患者32例(合并大血管病变组),并选择同期体检健康者30例(对照组)。采用酶联免疫法测定三组血浆FGF-21水平以及胰岛素强化治疗前后的变化,分析血浆FGF-21水平与体质量指数(BMI)、腰臀比(WHR)、血脂、血糖、空腹血浆胰岛素(FINS)和糖化血红蛋白(Hb A1C)等水平的关系。结果:T2DM组及T2DM合并大血管病变组患者空腹血浆FGF-21水平明显高于对照组(P<0.05),T2DM合并大血管病变组患者空腹血浆FGF-21水平明显高于T2DM组和对照组(P<0.05)。空腹血浆FGF-21水平与T2DM患者FPG、Hb A1C水平呈明显正相关,WHR、舒张压、Hb A1C是影响血浆FGF-21水平的独立相关因素。经胰岛素强化治疗后,血浆FGF-21水平较治疗前明显下降(P<0.05)。结论:T2DM患者血浆FGF-21水平明显升高,可能参与了T2DM及其大血管病变的发生和发展,胰岛素强化治疗可明显降低T2DM患者血浆FGF-21水平,血浆FGF-21可能作为T2DM病情和疗效评估的参考指标。
Objective： To explore the change of plasma fibroblast growth factor 21（FGF-21） in type 2 diabetes melli-tus（T2DM）patients with macroangiopathy, and to observe the effect of short-term intensive insulin therapy on FGF-21 level. Methods： Enzyme linked immunosorbent assay（ELISA） was used to detect plasma FGF-21 in 30 healthy controls（control group）, 32 patients with newly diagnosed T2DM（T2DM group） and 32 T2 DM patients with macroangiopathy（diabetic macroangiopathy group）. The change of FGF-21 before and after intensive insulin therapy was observed. The relationship of plasma FGF-21 with body mass index（BMI）, waist/hip ratio（WHR）, blood lipids, plasma glucose, fast-ing plasma insulin（FIN2） and glycosylated hemoglobin（Hb A1C） was analyzed. Results： Plasma level of FGF-21 in T2 DM patients with macroangiopathy was increased obviously. The fasting plasma FGF-21 level was positively correlated with FPG and Hb A1 C. The WHR, diastolic pressure and Hb A1 C were the independent factors influencing plasma level of FGF-21. Compared with before treatment, plasma level of FGF-21 after intensive insulin therapy was reduced obviously. Conclusion：Plasma FGF-21 may participate in the pathogenesis and development of T 2DM and diabetic macroangiopathy. Short-term intensive insulin therapy can obviously decrease plasma FGF-21 level in T2 DM patients.
出处
《现代生物医学进展》
CAS
2016年第33期6526-6528,共3页
Progress in Modern Biomedicine
