摘要
目的:探讨尖锐湿疣(CA)组织中朗格汉斯细胞(LC)的变化。方法:选取尖锐湿疣组30例,正常对照组10例,采用免疫组化法对尖锐湿疣组织和正常组织进行CD1a、S-100蛋白、HLA-DR检测,统计表达阳性的LC数量并观察其形态。结果:尖锐湿疣组织中的CD1a、S-100蛋白、HLA-DR阳性的LC表达均比正常组织降低。复发组与无复发组的表达也有差异。结论:尖锐湿疣组织中存在着LC的缺失和抗原提呈功能异常,这可能与尖锐湿疣的发病与复发有关。
Objectives： To investigate the changes and molecular mechanisms of Langerhans cells in the tissues of condyloma accuminatum（ CA）. Methods： 30 CA tissues and 10 normal tissues were observed by Histopathological of CD-1a ＋ LC,S-100 ＋ LC,HLA-DR ＋ LC. Results： Compared with normal tissues,the dendritic and express of CD-1a,S-100,HLA-DR in CA were decreased,especially in the recurrence group.Conclusion： CA lesions are characterized by decreased LC density and reduced function of antigen presenting,and this may cause the CA and its recurrence.
出处
《中国性科学》
2016年第11期75-78,共4页
Chinese Journal of Human Sexuality
基金
浙江省丽水市公益性应用技术项目(2012JYZB71)
