摘要
细胞外基质(ECM)在器官的形成、生长、功能和许多人类疾病中起重要作用。透明质酸(HA)是细胞外基质的主要成份之一,对肿瘤细胞的生长、分化、转移及血管新生有重要作用。在损伤部位HA碎片通过各种免疫细胞刺激炎症基因的表达。大血管和微血管病变是很多疾病,如糖尿病的主要并发症,由于代谢与HA合成之间紧密相关,有可能HA与糖尿病等疾病有紧密联系。血管平滑肌细胞源性的HA促进血管损伤后新内膜的形成,HA可能是潜在的治疗心血管疾病的靶标。文章主要综述HA与血管病变的关系。
Extracellular matrix（ECM）,formed in organ growth,plays an important role in many human diseases.Hyaluronic acid（HA） is one of the main components of the ECM,which plays an important role in tumor cell growth,differentiation,metastasis and angiogenesis. The expression of inflammatory genes is stimulated by various immune cells to stimulate the expression of HA in the damaged site. Macro- and microangiopathies are the major complications of many diseases such as diabetes,due to the close contact between the metabolism and HA synthesis,and it is possible to make HA and diabetes and other diseases have close contact. Vascular smooth muscle cell（VSMC） derived HA promotes the formation of new intima after vascular injury,and HA may be a potential target for the treatment of cardiovascular disease.This article mainly reviewed the relationship between HA and vascular disease.
出处
《中国动脉硬化杂志》
CAS
北大核心
2016年第11期1169-1172,共4页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金资助项目(81460155/H0705)
