摘要
目的：系统评价胰岛素泵治疗妊娠糖尿病的效果。方法计算机检索CNKI、VIP、万方、Sino-med、PubMed和Cochrane Library（2016年第3期）数据库，查找有关胰岛素泵应用于妊娠糖尿病的随机对照试验（ RCT），检索时限均为自建库至2016年3月。由2名研究者按照纳入与排除标准独立进行文献筛选、文献资料提取和文献的质量评价，而后采用RevMan 5.3软件进行Meta分析或仅进行描述性分析。结果最终纳入13项研究，共693例患者。 Meta分析或描述性分析结果显示：胰岛素泵组在降低空腹血糖、餐后2h血糖、糖化血红蛋白、血糖达标时间、胰岛素用量和低血糖发生例数方面的效果均优于常规皮下注射组，其差异均有统计学意义（ P〈0.05）。结论胰岛素泵可降低妊娠糖尿病患者的血糖，且低血糖发生例数减少。因受研究数量和研究质量的限制，本研究结论尚需要开展更多大样本、高质量的RCT加以证实。
Objective To systematically review the effect of insulin pump therapy in gestational diabetes.Methods Randomized control trials （ RCTs） related to insulin pump therapy in gestational diabetes were searched in databases such as Chinese National Knowledge Internet （ CNKI）, VIP, Wanfang Data, Sinomed, PubMed and the Cochrane Library （ Issue 3, 2016） from the date of establishment to March 2016. Two reviewers screened the literature according to the inclusion and exclusion criteria, extracted the data and assessed the quality of included studies independently. Meta-analysis was performed by RevMan 5.3 software, or only descriptive analysis was conducted instead. Results A total of 13 studies involving 693 patients were included. The results of meta-analysis descriptive analysis showed that the insulin pump therapy group was superior to the conventional subcutaneous insulin therapy group in reducing fasting blood glucose, 2-hour postprandial blood glucose, glycosylated hemoglobin, the time to achieve normal blood glucose, insulin dosage and the incidence of hypoglycemia, with statistically significant differences.Conclusions Insulin pump therapy can reduce the level of blood glucose for the patients with gestational diabetes, and it is also beneficial in reducing the incidence of hypoglycemia. However, because of the limitation of quantity and quality of the included studies, the conclusion should be further confirmed by conducting more large-scale and high quality RCTs.
出处
《中华现代护理杂志》
2016年第28期4015-4020,共6页
Chinese Journal of Modern Nursing
关键词
糖尿病
妊娠
Meta分析
随机对照试验
胰岛素输注系统
常规皮下注射胰岛素
Diabetes,pregnancy
Meta-analysis
Randomized controlled trial
Insulin infusion systems
Conventional subcutaneous insulin infusion
