摘要
1例患有冠心病、糖尿病、慢性肠炎和低蛋白血症等多种疾病的83岁女性患者，因阵发性房颤发作先后经左、右足背静脉持续泵入盐酸胺碘酮（浓度2 mg/ml）4和3 d，给药部位分别在给药后6和9 d各形成直径约5 cm的溃疡面。诊断为胺碘酮局部刺激致溃疡。给予清创、定期换药、抗感染（静脉滴注美罗培南）、改善微循环（静脉注射前列地尔）等处理。13 d后患者双足溃疡面出现新鲜肉芽，创面缩小，渗出液减少；46 d 后溃疡愈合。
An 83-year-old woman with coronary heart disease,diabetes mellitus,chronic enteritis and hypoproteinemia was received amiodarone hydrochloride（ 2 mg/ml ） continuously because of atrial fibrillation. Amiodarone hydrochloride was given by venous pump via her left and right lower extremity dorsal veins for 4 and 3 days,respectively. The skin of injection sites on her double feet appeared cover surfaces of ulcers with diameter of 5 cm on 6 and 9 days after intravenous administration,respectively. she was diagnosed as ulcer due to amiodarone＇s local stimulation. The patient received surgical debridement,regular dressing,an IV infusion of meropenem for preventing infection,and intravenous injection of alprostadil for improving microcirculation. Thirteen days later,the fresh granulation appeared on her double feet ulcer surface,the area of ulcer was lessened,and the exudate reduced. Forty-six days later,her ulcer was healed.
出处
《药物不良反应杂志》
CSCD
2016年第5期392-394,共3页
Adverse Drug Reactions Journal
