摘要
目的:研究瓦里安Eclipse计划系统中基于基部剂量计划补偿(BDPC)的调强放射治疗计划优化方法在睾丸精原细胞瘤放疗中的可行性。方法:选取15例睾丸精原细胞瘤患者,医师勾画靶区及危及器官,通过RTIS网络传输至Eclipse治疗计划系统,物理师将较长靶区分两段,分别用3D-CRT和BDPC制定放疗计划。评价靶区适形度指数、均匀性指数和危及器官受量,并分析射野衔接处的剂量和二次摆位误差。结果:利用BDPC制定的调强放射治疗计划提高了靶区适形度指数,改善了靶区内的剂量均匀性。利用Delta4验证设备测量射野衔接处的剂量分布,未出现剂量冷热点,与计算值基本一致;CBCT图像引导技术验证了利用加速器移床方法二次摆位误差各方向均为零。结论:BDPC优化方法在睾丸精原细胞瘤"狗腿"野的应用能提高靶区适形指数,改善射野衔接处的剂量分布;通过移床方法确保治疗位置准确性,避免二次摆位误差造成的射野衔接处的剂量冷热点,从而简化了整体治疗过程。
Objective To study on the feasibility of base dose plan compensation （BDPC） optimization method of Eclipse treatment planning system （TPS） in the intensity-modulated radiotherapy （IMRT） for testicular seminoma. Methods The target areas and organs at risk of 15 selected patients with tesficular seminoma were delineated by physicists, and then transmitted into Eclipse TPS by RTIS transmission networks. The longer target areas were broke up into two segments by physicists, and the three-dimensional conformal radiotherapy （3D-CRT） and BDPC were used for plan design, respectively. The conformity index （CI）, homogeneity index （HI）, and dose of organs at risk were evaluated, and the dose of abutting field and secondary set- up error were analyzed. Results IMRT plan based on BDPC improved the target CI and HI. Delta4 verification equipment was used to measure the dosimetric distribution of abutting field, without appearing cold and hot spots, basically consistent with the calculated values. CBCT image guided technology verified that the secondary set-up error in each direction was zero by using the bed moving method with accelerator. Conclusion BDPC optimization method in the dogleg field of testicular seminoma increases the target CI,and improves the dose distribution of abutting field. The bed moving method ensures the accuracy of the treatment position, and avoids the hot or cold spots at the abutting field caused by secondary set-up errors, simplifying the overall treatment process.
出处
《中国医学物理学杂志》
CSCD
2016年第11期1086-1091,共6页
Chinese Journal of Medical Physics
基金
国家自然科学基金(11275105)
