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脚桥核低频深部脑刺激治疗帕金森病的研究进展 被引量:8

Recent advance in clinical research of low-frequency deep brain stimulation of pedunculopontine nucleus in Parkinson's disease
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摘要 深部脑刺激疗法已被普遍用于治疗多种功能性神经疾病。尽管高频电刺激丘脑底核可改善帕金森病患者的静止性震颤、运动迟缓和肌肉强直等典型症状。但是对于晚期帕金森病的轴线状态如姿势异常及步态障碍并没有很好的改善作用。目前有研究发现低频刺激脚桥核能改善帕金森病患者姿势异常及步态障碍的轴性症状。本文围绕近年来低频刺激脚桥核治疗帕金森病的相关研究进展综述如下。 Deep brain stimulation (DBS) has been widely used in the treatment of a variety of functional neurological diseases. The high-frequency electrical stimulation of subthalamic nucleus can improve tremor, bradykinesia, and rigidity of patients with Parkinson's disease, however, the effects of DBS on gait and balance disorders don't get very good improvement. Recently, clinical studies have found that low frequency pedunculopontine nucleus stimulation can relieve these axial symptoms. Hence we will summarize the clinical researches on the low-frequency deep brain stimulation of pedunculopontine nucleus.
出处 《中华神经医学杂志》 CAS CSCD 北大核心 2016年第11期1185-1188,共4页 Chinese Journal of Neuromedicine
基金 国家自然科学基金(81271250) 国家临床重点建设专科资助项目 广东省神经外科临床中心资助项目
关键词 帕金森病 脚桥核 深部脑刺激 Parkinson's disease Pedunculopontine nucleus Deep brain stimulation
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  • 2Breit S, Bouali - Benazzouz R, Benabid AL, et al. Unilateral lesion of the nigrostriatal pathway induces an increase of neuronal activity of the pedunculopontine nucleus, which is reversed by the lesion of the subthalamic nucleus in the rat. EurJ Neurosci, 2001, 14( 11): 1833-1842. 被引量:1
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