摘要
血栓的形成严重影响了人类的健康,迄今为止尚未明确其形成机制。研究发现,血小板上的一种受体GPIbα,在血栓的形成中发挥重要作用。GPIbα通过与凝血酶和VWF的结合而激活血小板,是促成血栓的形成的主要途径;结合位点位于GPIbα的265-288残基区域,并受到其他区域的调节。其他途径,如GPIbα的膜外功能区脱落形成s GPIb,同样也会对血栓的形成造成影响。体内多种因素的影响,如PARs、ADAM-17和14-3-3ζ等,会对GPIbα的生理功能造成影响,并最终影响了血栓的形成。本文主要对目前基于GPIbα受体的血栓形成研究成果,对GPIbα的结构、功能和介导血栓形成的机制作一综述,期望对血栓形成和治疗的进一步研究起到一定的帮助。
The thrombosis disease is a serious hazard to human health, but the mechanism of it was not clear. It has been reported that GPIbα, one of the receptors on platelet, is crucial in thrombosis disease. Platelet activation is of critical importance for the mechanism of thrombosis disease, mediated by the binding of thrombin and VWF to GPIbα. The binding sites locate on the 265-288 residues of GPIbα and the binding is regulated by other regions of GPIbα. In addition, other approaches, such as s GPIb caused by ectodomain shedding of GPIbα, also lead to thrombosis disease. The function of GPIbα is affected by some factors like PARs,ADAM-17, 14-3-3ζ and so on. Recent researches of the construction, function and mechanism of GPIb α were reviewed in this article.The purpose of this review is to provide new ways to explore the mechanism and treatment of thrombosis disease.
出处
《现代生物医学进展》
CAS
2016年第32期6394-6396,6255,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(81373415)
