摘要
目的:系统评价糖脉康颗粒/片联合常规降糖药治疗糖尿病肾脏病(DKD)的疗效,为临床提供循证参考。方法:计算机检索Medline、EMBase、Cochrane图书馆、中国生物医学文献数据库、中国期刊全文数据库、万方数据库和中文科技期刊数据库,收集糖脉康颗粒/片联合常规降糖药(试验组)对比单用常规降糖药(对照组)治疗DKD的相关试验,提取资料并进行质量评价后,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入9项RCT,合计883例患者。Meta分析结果显示,试验组患者临床有效率显著高于对照组[OR=4.88,95%CI(2.56,9.32),P<0.001],血肌酐(Scr)[MD=-28.48,95%CI(-34.90,-22.06),P<0.001]和24 h尿蛋白定量[MD=-100.26,95%CI(-106.00,-94.52),P<0.001]显著低于对照组,差异均有统计学意义。两组患者血尿素氮(BUN)水平比较差异无统计学意义[MD=-0.85,95%CI(-1.36,-0.34),P=0.001]。结论:糖脉康颗粒/片联合常规降糖药治疗DKD的疗效较好,可降低患者的Scr和24 h尿蛋白定量。
OBJECTIVE： To systematically review the efficacy of Tangmaikang tablet combined with conventional hypolycemic agents in the treatment of diabetic kidney disease, and provide evidence-based reference for clinic. METHODS： Retrieved from Medline, EMBase, Cochrane Library, CBM, CJFD, Wanfang Database and VIP, randomized controlled trials （RCT） about Tangmaikang tablet combined with western medicine （test group） versus western medicine alone （control group） in the treatment of diabetic kidney disease were collected. Meta-analysis was performed by Rev Man software after data extraction and quality evaluation. RESULTS： Totally 9 RCTs were included, involving 883 patients. Results of Meta-analysis showed, the clinical effective rate in test group were significantly higher than control group [OR： 4.88,95 % CI （2.56,9.32）, P〈 0.001], Scr level[MD = - 28.48,95 % CI （-34.90,22.06） ,P〈0.001] and 24 h urinary protein excretion [MD=- 100.26,95%CI（- 106.00,-94.52） ,P〈0.001], with sta- tistical significance; there was no significant difference in BUN level in 2 groups [MD=-0.85, 95% CI （- 1.36,- 0.34）, P= 0.001]. CONCLUSIONS： Tangmaikang granule/tablet combined with conventional hypoglycemic agents has good efficacy in the treatment of diabetic kidney disease, which can reduce patients＇ Scr and 24 h urinary protein excretion.
出处
《中国药房》
CAS
北大核心
2016年第33期4671-4674,共4页
China Pharmacy
基金
国家中医药管理局全国名老中医药专家传承工作室建设项目(No.国中医药人教发[2014]20号)
国家中医药管理局中医药标准化项目(No.SATCM-2015-BZ[204])
关键词
糖尿病肾脏病
糖脉康颗粒
糖脉康片
系统评价
疗效
Diabetic kidney disease
Tangmaikang granule
Tangmaikang tablet
Systematic review
Eitiicacy
