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地西他滨治疗骨髓增生异常综合征的临床疗效探讨

Clinical Efficacy of the Treatment of Patients With Bone Marrow Hyperplasia Syndrome With Decitabine
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摘要 目的探讨在骨髓增生异常综合征治疗中应用地西他滨的效果。方法对我院近年来收治的46例骨髓增生异常综合征患者进行回顾性分析,依据患者入院就诊时间分为参照组与实验组,每组患者例数23例,参照组治疗中实行常规HA方案疗法,实验组治疗中予以地西他滨,对比两组患者并发症发生率与治疗效果。结果实验组患者有效率是95.65%、并发症发生率为4.34%,均优于参照组的有效率65.21%、并发症发生率26.08%,P<0.05,差异有统计学意义。结论将地西他滨疗法应用在骨髓增生异常综合征中具有显著效果,可以降低并发症发生率,改善治疗效果。 Objective To study the application in the treatment of myelodysplastic syndrome the effect of decitabine. Methods 46 cases of myelodysplastic syndrome were retrospectively analyzed in our hospital, on the basis of treatment time of patients admitted into control group and experimental group, each group with 23 cases, according to the implementation of conventional HA scheme in the treatment of treatment group, the experimental group in the treatment of decitabine, were compared between the two groups the occurrence rate of complications and treatment effect. Results The effective rate of the experimental group was 95.65%, the incidence of complications was 4.34%, the effective rate of the reference group was 65.21%, the incidence of complications was 26.08%, P〈0.05, the difference was statistically significant. Conclusion The application of the treatment of the western medicine in the treatment of patients with bone marrow hyperplasia has a significant effect, which can reduce the incidence of complications and improve the treatment effect.
作者 马丽丽
出处 《中国继续医学教育》 2016年第30期136-137,共2页 China Continuing Medical Education
关键词 地西他滨 骨髓增生异常综合征 临床疗效 Decitabine Myelodysplastic syndrome Clinical curative effect
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  • 1徐泽锋,肖志坚.地汐他滨治疗骨髓增生异常综合征的研究进展[J].中华血液学杂志,2007,28(1):61-64. 被引量:4
  • 2Shen L,Kantarjian H,Guo Y,et al.DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes[J].J Clin Oncol,2010,28(4):605-13. 被引量:1
  • 3Garcia JS,Jain N,Godley LA.An update on the safety and efficacy of decitabine in the treatment of myelodysplastic syndromes[J]. Onco Targets Ther,2010,3(3):1-13. 被引量:1
  • 4Sekeres MA.Treatment of MDS:something old,something new, something borrowed[C].Am Soc Hematol Educ Program.2009: 656-63. 被引量:1
  • 5Momparler RL.Pharmacology of 5-aza-2'-deoxycytidine(decitabine) [J].Semin Hematol,2005,42(1):S9-S16. 被引量:1
  • 6Oki Y,Aoki E,Issa JP.Decitabine-bedside to bench[J].Crit Rev Oncol Henatol,2007,61(2):140-52. 被引量:1
  • 7Bhalla KN.Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies[J].J Clin Oncol,2005,23:3971-93. 被引量:1
  • 8Kantarjian H,Oki Y,Garcia-Manero G,et al.Results of a randomized study of 3 schedules of low-dose decitabine in higherrisk myelodysplastic syndrome and chronic myelomonocytic leukemia[J].Blood,2007,109(1):52-7. 被引量:1
  • 9Nimer SD. Myelodysplastic syndromes. Blood, 2008, 111:4841-4851. 被引量:1
  • 10Plimaek ER, Kantarjian HM, Issa JP. Decitabine and its role in the treatment of hematopoiefic malignancies. Leuk Lymphoma, 2007, 48: 1472-1480. 被引量:1

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