摘要
目的:分析全髋关节置换术后使用桃红四物汤对凝血功能、疼痛程度以及RANKL、OPG含量的影响。方法:118例接受全髋关节置换术治疗的患者分为观察组及对照组,对比两组患者术后12d血清凝血指标、纤溶指标、疼痛介质、炎症介质及RANKL、OPG含量。结果:观察组患者的术后12d血清凝血指标PT、APTT、TT水平大于对照组患者,D-D含量低于对照组患者;纤溶指标FIB、FDP、PAI-1、t-PA含量低于对照组患者,Plg、u-PA含量高于对照组患者;血清疼痛介质β-EP、NO、CGRP、SP、PGE2含量低于对照组患者;血清炎症介质hs-CRP、IL-6、TNF-α、IL-17、IL-33、TREM-1含量低于对照组患者;血清RANKL、OPG含量低于对照组患者。结论:桃红四物汤可优化全髋关节置换术后患者的凝血功能、降低疼痛感受,在促进患者远期骨折愈合方面也有积极意义。
Objective： To analyze the effects of using Taohongsiwu decoction after total hip replacement on blood coagu- lation function, pain degree as well as RANKL and OPG content. Methods.. A total of 118 patients who underwent total hip re- placement were divided into observation group and control group, and serum blood coagulation indexes, fibrinolysis indexes, pain mediators and inflammatory mediators as well as RANKL and OPG content were compared between two groups of pa- tients 12d after operation. Results： Blood coagulation indexes PT, APTT and TT levels of observation group 12d after opera- tion were greater than those of control group while D-D content was lower than that of control group; fibrinolysis indexes FIB, FDP, PAI-1 and t-PA content in serum were lower than those of control group while Plg and u-PA content were higher than those of control group：pain mediators β-EP, NO, CGRP, SP and PGE2 content in serum were lower than those of control group：inflammatory mediators hs-CRP, IL-6, TNF-a, IL-17, IL-33 and TREM-1 content in serum were lower than those of control group; RANKL and OPG content in serum were lower than those of control group. Conclusion： Taohongsiwu decoction can optimize patients＇ blood coagulation function and reduce the perception of pain after total hip replacement, and is also of positive significance in promoting patients＇ long-term fracture healing.
出处
《海南医学院学报》
CAS
2016年第22期2728-2731,共4页
Journal of Hainan Medical University
基金
武汉市卫计委医疗卫生科研医疗项目(WX11C16)~~
关键词
全髋关节置换术
桃红四物汤
凝血功能
疼痛程度
Total hip replacement
Taohongsiwu decoction
Blood coagulation function
Pain degree
