摘要
目的 研究二甲双胍在多囊卵巢综合征促排卵治疗中的作用。方法 选取2014年4月~2015年1月我院收治多囊卵巢综合征患者83例并随机分组,K组采用克罗米芬进行治疗,K＋E组在K组基础上增加二甲双胍进行治疗。对比干预结果。结果 K＋E组较之K组临床总有效率、妊娠率更高,干预后K＋E组较之K组空腹血糖、空腹胰岛素、黄体生成素、性激素结合球蛋白、黄体生成素、促卵泡素、睾酮改善更显著（P〈0.05）。K＋E组、K组药物不良反应发生率相似,均无严重不良反应发生（P〉0.05）。结论 二甲双胍在多囊卵巢综合征促排卵治疗中的作用确切,值得推广。
Objective To explore the effect of metformin on ovulation induction in women with polycystic ovary syndrome. Methods 83 cases of patients with polycystic ovary syndrome in our hospital from April 2014 to January were randomly divided into K group and K＋E group.Patients in K group were treated by clomiphene,and patients in K＋E group were treated with metformin on the basis of the K group.Intervention results of the two groups were compared. Results The clinical total effective rate and pregnancy rate in the K＋E group were higher than those of K group.Compared with the K group,the K＋E group was more significantly improved on fasting blood glucose,fasting insulin, progesterone,sex hormone binding globulin,progesterone and testosterone（P 〈 0.05）.The incidence of adverse drug reactions was similar in K＋E group and K group.No serious adverse reactions occurred（P 〉 0.05）. Conclusion The effect of metformin on ovulation induction in women with polycystic ovary syndrome is definite,and it is worth popularizing.
出处
《中国医药科学》
2016年第17期87-89,共3页
China Medicine And Pharmacy
