摘要
目的 探讨宫瘤消胶囊联合米非司酮治疗对子宫肌瘤患者疗效及血清E2、LH、P水平的影响。方法 选取2012年4月~2014年12月我院收治子宫肌瘤患者80例,随机分为A、B两组,各40例,B组患者给予口服米非司酮片30mg/d,疗程6个月;A组在B组治疗的基础上加口服宫瘤消胶囊3粒/次,3次/d,疗程6个月。观察两组患者临床疗效、治疗前后黄体生成素（LH）、雌二醇（E2）、孕激素（P）水平和不良反应,并对两组情况进行对比分析。结果 治疗后,两组患者E2、LH、P水平均较治疗前下降,差异具有统计学意义（P〈0.05）,且A组患者E2、LH、P水平下降幅度大于B组,差异有统计学意义（P〈0.05）。两组患者子宫体积、肌瘤体积均较治疗前有显著性减少,差异有统计学意义（P〈0.05）,A组患者子宫体积、肌瘤体积减少的幅度大于B组,差异有统计学意义（P〈0.05）。A组总有效率92.5%;B组总有效率75%,两组患者临床疗效差异有统计学意义（P〈0.05）。两组患者不良反应发生率分别12.5%、17.5%;两者差异无统计学意义（P〉0.05）。结论 宫瘤消胶囊与非米司酮联合治疗子宫肌瘤,缩小肌瘤体积,降低性激素水平,有效的改善患者的临床症状,安全有效。
Objective To investigate the effect of Gongliuxiao capsule combined with mifepristone in treatment of patients with uterine fibroids and its influence on serum E2,LH and P levels. Methods 80 cases of patients with uterine fibroids cured in our hospital from April 2012 to December 2014 were selected. According to the random distribution,all patients were divided into group A （n=40） and group B（n=40）.Patents in group B were treated with oral mifepristone tablets 30mg/d,for 6 months.On this basis,patients in group A were treated with oral palace tumor Xiao capsule 3 capsules/time,TID,for six months.Clinical curative effect,progesterone （LH） before and after the treatment,estradiol （E2）,progesterone （P） levels and adverse reactions of patients in the two groups were observed.And conditions of the two groups were comparatively analyzed. Results After treatment,E2,LH and P levels of patients in two groups were lower than those before treatment,the difference was statistically significant （P 〈 0.05）.And E2,LH and P levels decline ranges of patients in group A were significantly lower than those of group B,there were statistically significant differences （P 〈 0.05）.Uterine volume and fibroid volume of patients in the two groups were significantly reduced,and the differences were statistically significant （P 〈 0.05）.Uterine volume and fibroid volume decline ranges of group A group were bigger than those of group B,the differences were statistically significant （P 〈 0.05）.The total effective rate of group A was 92.5%;the total effective rate of group B was 75%,and there were significant differences between the two groups （P 〈 0.05）.The incidence of adverse reactions in the two groups were 12.5% and 17.5%respectively,and there was no significant difference （P 〉 0.05）. Conclusion Gongliuxiao capsule combined with mifepristone in treatment of uterine fibroids can reduce tumor volume,reduce the level of sex hormones,and effectively improve the patient’s clinical symptom
出处
《中国医药科学》
2016年第17期62-65,共4页
China Medicine And Pharmacy
关键词
子宫肌瘤
宫瘤消胶囊
米非司酮
疗效
Uterine fibroids
Gongliuxiao capsule
Mifepristone
Curative effect
