摘要
目的探讨系统性红斑狼疮（SLE）成年女性患者月经及相关情况的变化。方法选取2015年11月至2016年4月西安交通大学第一附属医院风湿免疫科收住入院的72例SLE成年女性患者,选取同期来自本院体检中心60例健康成年女性作为对照,比较SLE患者与健康对照者月经、绝经、生育史等情况,评估SLE疾病活动指数及糖皮质激素治疗剂量对女性月经情况的影响。结果在入选的72例SLE成年女性患者中,75.00%（54/72）出现月经异常,SLE患者中绝经年龄较健康对照者提前（t=3.477,P〈0.05）。已婚的SLE患者中流产或异常产比例高于健康对照者（χ^2=6.610,P〈0.05）。与无月经异常表现的SLE患者相比,有月经异常表现的SLE患者的疾病活动性指数（SLEDAI）评分相对较高（t=2.451,P〈0.05）、糖皮质激素服用剂量（mg/d）相对较大（t=2.086,P〈0.05）,在SLE发病年龄、病程、初潮年龄、体重指数方面无差异（t值分别为0.418、1.692、1.622、0.289,均P〉0.05）。结论 SLE患者中月经异常、流产或异常产比例较高,绝经年龄提前,有月经异常的SLE患者病情活动度相对高,服用糖皮质激素的平均剂量较大,医护人员需关注SLE患者的月经及相关情况的变化,对SLE患者提供更适宜的治疗方案和护理措施,提高SLE成年女性患者的生活质量。
Objective To evaluate the menstruation and related conditions in adult female patients with systemic lupus erythematosus（ SLE）. Methods Seventy-two SLE adult female patients admitted to the department of rheumatology in the First Affiliated Hospital of Xi＇an Jiaotong University were selected from November 2015 to April 2016,and 60 cases of the healthy adult women were selected in the same period as controls. The situations of menstruation,menostasis and reproductive history were compared between patients and healthy controls to evaluate systemic lupus erythematosus disease activity index（ SLEDAI） and the influence of prednisone doses on menstruation for women. Results Of 72 adult female patients with SLE,75. 00% had menoxenia. Compared to the heath controls,age of menostasis in SLE patients was younger（ t = 3. 477,P〈0. 05）,the proportion of miscarriages or metatocia history was also higher（ χ^2= 6. 610,P〈0. 05）. The SLEDAI score of SLE patients with menoxenia was much higher（ t = 2. 451,P〈0. 05） and doses of prednisone（ mg / day）was more compared to those with normal menstruation（ t = 2. 086,P〈0. 05）. There was no difference in onset age,course of SLE,age of menophania and Body Mass Index（ t value was 0. 418,1. 692,1. 622 and 0. 289,respectively,all P〉0. 05）. Conclusion SLE patients have higher rates of menoxenia and miscarriages or metatocia history,and their age of menostasis is younger than heath controls. SLE patients with menoxenia have higher SLEDAI score and more dose of prednisone treatment. Medical workers should pay close attention to the changes of menstruation in SLE female patients and provide more suitable treatment and measures to improve the quality of their life.
作者
李欣
王香丽
张乐
石燕杰
何岚
王明旭
LI Xin WANG Xiang-li ZHANG Le SHI Yan-jie HE Lan WANG Ming-xu(Department of Rheumatology Department of Obstetrics, First Affiliated Hospital of Xi＇ an Jiaotong University, Shaanxi Xi ＇ an 710061,China School of Public Health, Faculty of Medicine of Xi＇ an Jiaotong University, Shaanxi Xi＇ an 710061, China)
出处
《中国妇幼健康研究》
2016年第10期1201-1203,共3页
Chinese Journal of Woman and Child Health Research
关键词
系统性红斑狼疮
月经
绝经
流产或异常产史
疾病活动性指数
systemic lupus erythematosus（SLE）
menstruation
menostasis
miscarriage or metatocia history
systemic lupus erythematosus disease activity index（SLEDAI）
