摘要
目的通过分析AST与PLT比值（APRI）、FIB-4、Forns指数、S指数和Fibro Scan与肝纤维化程度的关系及其相关性,评价其单独、联合应用对肝纤维化的诊断价值,探讨其无创评估慢性乙型肝炎（CHB）患者肝纤维化程度的临床应用价值。方法回顾性收集2009年1月-2015年4月于宁夏医科大学总院就诊的行肝穿刺活组织检查,并经病理诊断证实为CHB的患者91例,根据Scheuer分级,按患者的肝纤维化程度（S）分为3组,即无肝纤维化组（纤维化分期为S0,n=32）,
Objective To investigate the correlation of aspartate aminotransferase to platelet ratio index（ APRI）,FIB-4,Forns index,S index,and Fibro Scan with the degree of liver fibrosis,the diagnostic value of these techniques used alone or in combination,and the clinical value of these noninvasive techniques in the assessment of the degree of liver fibrosis in patients with chronic hepatitis B（ CHB）. Methods A retrospective analysis was performed for the clinical data of 91 patients with pathologically confirmed CHB who visited General Hospital of Ningxia Medical University and underwent liver biopsy from January 2009 to April 2015. According to the Scheuer pathological stage and liver fibrosis stage（ S）,the patients were divided into non-liver fibrosis group（ a liver fibrosis stage of S0,32 patients）,mild liver fibrosis group（ a liver fibrosis stage of S2,30 patients）,and marked liver fibrosis group（ a liver fibrosis stage of ≥S2,29 patients）. The APRI,FIB-4,Forns index,and S index were calculated,and liver stiffness was measured by Fibro Scan. An analysis of variance was used for the comparison of normally distributed continuous data between three groups,and the Dunnett t-test was used for further comparison between any two groups. The Spearman correlation analysis was also performed. Sensitivity,specificity,and area under the receiver operating characteristic curve（ AUC） were used to evaluate the value of these noninvasive techniques in the diagnosis of liver fibrosis. Results There were significant differences in age,albumin,aspartate aminotransferase,alanine aminotransferase,and platelet count between the three groups（ F = 3. 552,4. 035,4. 374,and 5. 992,all P〈0. 05）,and there were significant differences in these parameters between the non-liver fibrosis group and the mild and marked liver fibrosis groups（ P〈0. 05）. There were significant differences in APRI,FIB-4,Forns index,S index,and Fibro Scan between the three groups（ F = 4. 579,5. 728,10. 501,14. 118,and 30. 039,al
出处
《临床肝胆病杂志》
CAS
2016年第10期1888-1893,共6页
Journal of Clinical Hepatology
关键词
肝硬化
肝炎
乙型
慢性
诊断技术和方法
对比研究
liver cirrhosis
chronic hepatitis B
diagnostic techniques and procedures
comparative study
