摘要
目的探讨阿司匹林联合氯吡格雷治疗大脑中动脉狭窄脑梗死的临床效果。方法大脑中动脉狭窄脑梗死患者168例,随机分两组,对照组84例采用阿司匹林治疗,观察组84例采用阿司匹林联合氯吡格雷治疗,于治疗前后行Barthel指数、Fugl-Meyer评分、NIHSS评分、VAS评分,并检测血流动力学指标(全血低切黏度、全血高切黏度、血浆黏稠度、纤维蛋白原),比较两组临床疗效、预后。结果治疗后,两组Barthel指数、Fugl-Meyer评分增加(P<0.05)。两组NIHSS评分、VAS评分、血流动力学指标(全血低切黏度、全血高切黏度、血浆黏稠度、纤维蛋白原)降低(P<0.05)。观察组Barthel指数、Fugl-Meyer评分、治疗总有效率高于对照组(P<0.05)。观察组NIHSS评分、VAS评分、血流动力学指标(全血低切黏度、全血高切黏度、血浆黏稠度、纤维蛋白原)、并发症发生率、疾病进展率、疾病复发率低于对照组(P<0.05)。结论阿司匹林联合氯吡格雷治疗大脑中动脉狭窄脑梗死的疗效显著。患者临床指标、神经功能改善明显,预后较好。
Objective To investigate clinical effect of aspirin combined with clopidogrel in treatment of middle cerebral artery stenosis cerebral infarction. Methods 168 cases of patients with middle cerebral artery stenosis cerebral infarction were randomly divided into 2 groups. 84 patients were divided into control group and treated with aspirin. 84 patients were divided into observation group and treated aspirin combined with clopidogrel. Barthel index, Fugl-Meyer score, N1HSS score, VAS score evaluated before and after treatment were detected, and hemodynamic indexes （low blood viscosity, whole blood viscosity, plasma viscosity, fibrinogen） were also detected. Clinical efficacy and prognosis were compared between two groups. Results After treatment, Barthel index and Fugl-Meyer score were increased in two groups （P 〈 0.05）. NIHSS score, YAS score, hemodynamic indexes （low blood viscosity, whole blood viscosity, plasma viscosity, fibrinogen） were decreased in two groups （P 〈 0.05）. Barthel index, Fugl-Meyer score, total effective rate in observation group were higher than those in control group （P 〈 0.05）. NIHSS score, VAS score, hemodynamic indexes （low blood viscosity, whole blood viscosity, plasma viscosity, fibrinogen）, complication rate, disease progression rate, disease recurrence rate in observation group were lower than those in control group（P 〈 0.05）. Conclusion Aspirin combined with clopidogrel have significant effect in treatment of middle cerebral artery stenosis cerebral infarction has significant effect. Clinical parameters and neurological function were significantly improved, and the prognosis is good.
出处
《中国医药科学》
2016年第16期156-159,共4页
China Medicine And Pharmacy
关键词
阿司匹林
氯吡格雷
大脑中动脉狭窄脑梗死
Aspirin
Clopidogrel
Middle cerebral artery stenosis cerebral infarction
