摘要
目的观察奥卡西平治疗部分性发作癫痫患儿的疗效及不良反应。方法对2011年1月至2014年12月就诊于西安市儿童医院神经科门诊的部分性发作癫痫患儿220例,采用逐步加量方法口服奥卡西平,起始剂量为8~10mg·kg^(-1)·d^(-1),目标剂量为20~40mg·kg^(-1)·d^(-1),分2次口服;分别于服药2年、4年为时间点,随访观察比较不同时间的疗效、保留率、不良反应的差异。结果奥卡西平服药2年、4年的有效率分别为86.82%和89.42%,两组疗效差异无统计学意义(χ~2=0.652,P=0.448);服药保留率分别为86.82%和89.42%;总的发生不良反应率为8.18%,常见皮疹、嗜睡和肝功损害。结论奥卡西平治疗儿童部分性发作癫痫的疗效显著,不良反应小,保留率高,具有较好的依从性和耐受性。
Objective To observe the therapeutic efficacy and adverse reactions of oxcarbazepine on partial epilepsy of children. Methods Totally 220 children with partial epilepsy,admitted to Xi＇an Children Hospital from January 2011 to December 2014,were chosen in study.They were treated with oxcarbazepine with an initial dose of 8-10 mg/（ kg·d） and target dose of 20-40 mg/（ kg·d）,orally taking 2 times every day. The therapeutic efficacy,retention rate and adverse reactions 2 and 4 years after treatment were investigated. Results The total effective rates at 2 and 4 years after treatment were 86. 82% and 89. 42%,respectively,and the difference was not significant（ χ~2= 0. 652,P = 0. 448）. The retention rates at 2 and 4 years after treatment were 86. 82% and 89. 42%,respectively. The incidence of adverse reactions was 8. 18%,and the major complications included rash,drowsiness and liver damage. Conclusion Treatment with oxcarbazepine is effective with less adverse reactions and high retention rate on partial epilepsy of children,and the compliance and tolerance are high.
出处
《中国妇幼健康研究》
2016年第9期1122-1123,共2页
Chinese Journal of Woman and Child Health Research
关键词
奥卡西平
部分性发作
疗效
保留率
不良反应
oxcarbazepine（OXC）
partial epilepsy
therapeutic efficacy
retention rate
adverse reaction
