摘要
目的:建立我国儿童临床用药综合评价方法。方法:采用文献研究法和专家咨询法,梳理综合评价方法建立的理论基础及可行性,采用层次分析法建立儿童用药循证综合评价方法。结果:基于层次分析原理,通过构建指标体系、确定指标权重、构建证据体和证据质量评价、以及综合评分四个过程开展儿童药物循证综合评价,并以六种大环内酯类药物为例进行实证研究,证实其可行性。结论:以层次分析法为基础的儿童用药循证综合评价方法能客观地衡量多个药品之间的优劣关系,为儿童临床合理用药提供依据。
Objective：To set up a method for comprehensive evaluation of clinical medication in pediatrics in China.Methods：After literature research and expert consultation,this comprehensive evaluation method was built on the analytic hierarchy process theory.Results：This method contain four processes,including index system development,index weight balancing,evidence matrix and quality construction,and integrated assessment process based on analytic hierarchy process.Its feasibility was confirmed by a practical empirical research of six macrolides.Conclusion：The evidence-based comprehensive pediatric drug evaluation method could weigh the pros and cons among different drugs and provide evidence for rational drug use.
作者
贾露露
孟瑶
刘亦韦
尉耘翠
郭志
彭晓霞
王晓玲
Jia Lulu Meng Yao Liu Yiwei Yu Yuncui Guo Zhigang Peng Xiaoxia Wang Xiaoling(Beijing Children＇s Hospital Affiliated to Capital Medical University, Beijing 100045, China School of Pharmaceutical Sciences, Peking University)
出处
《药物流行病学杂志》
CAS
2016年第10期601-605,共5页
Chinese Journal of Pharmacoepidemiology
基金
国家卫计委药政司委托课题(编号:药政[2015]15号)
中国-世卫组织2014-2015双年度合作项目(编号:WPCHN1408195,5.1,61775)
关键词
层次分析法
儿童药物
循证
综合评价方法
Analytic hierarchy process
Pediatric drug
Evidence-based evaluation
Comprehensive evaluation method
