摘要
苯并吡喃骨架存在于许多天然及合成的生物活性物质中,因此发展其高效合成方法极具实用价值.本工作以氯化锌为催化剂催化酚与异戊烯基溴发生傅克/氢烷氧化串联反应,高效合成了一系列苯并吡喃化合物.该方法所用催化剂简单易得,催化剂用量少,反应条件温和,为苯并吡喃类化合物的合成提供了一种高效且实用的路径.
Chroman skeleton exists in many natural and synthetic biologically active materials. A highly efficient method for the synthesis of chromans via reaction of phenols with prenyl bromide catalyzed by zinc chloride is described, which provides a practical process to afford this type of biologically important compounds in good yields using commercially available and inexpensive catalyst under mild conditions.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2016年第10期2499-2503,共5页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.21272168)资助项目~~
