摘要
目的探讨在急性脑梗死患者治疗中,应用阿托伐他汀防治颈动脉粥样硬化斑块的效果。方法对我院收治的320例急性脑梗死患者进行研究。将患者随机分为观察组与对照组,每组160例。两组患者均给予常规治疗,观察组在常规治疗的基础上,服用阿托伐他汀药物。对比两组患者治疗前后6个月的血脂水平与颈动脉内膜中膜厚度(IMT)变化情况。结果治疗前,两组患者血脂各项指标差异无统计学意义(P>0.05);治疗后,观察组患者的血清TC、HDL、TG、LDL、IMT水平显著降低(P<0.05),对照组的变化不明显(P>0.05),两组相比,差异有统计学意义(P<0.05)。结论在急性脑梗死患者治疗中,应用阿托伐他汀药物,能够有效防治颈动脉粥样硬化斑块,使动脉粥样硬化控制稳定,值得在临床上大力推广。
Objective To investigate the effect of atorvastatin on carotid atherosclerotic plaque in patients with acute cerebral infarction. Methods Three hundred and twenty cases of patients with acute cerebral infarction in our hospital were selected as study objects, and divided into observation group and control group, with 160 cases in each group. Patients in the two groups were both given conventional treatment. On the basis of conventional treatment, the observation group received atorvastatin. The blood lipid levels and carotid artery intima media thickness （IMT） before and 6 months after the treatment were compared between the two groups. Results Before the treatment, the blood lipid indexes bad no significant difference between the two groups （P〉0.05） ; after the treatment, the serum levels of TC, HDL, TG, LDL, IMT significantly decreased in the observation group （P〈0.05）, while the changes of these indexes in the control group were not obvious （P〉0.05）, and the difference was statistically significant between the two groups （P〈0.05）. Conclusion Atorvastatin applied in the treatment of patients with acute cerebral infarction can effectively control the carotid atherosclerotie plaque, so as to achieve stable atherosclerosis, which is worthy to be popularized in clinic.
出处
《临床医学研究与实践》
2016年第23期79-80,共2页
Clinical Research and Practice
