摘要
目的:研究阿德福韦酯治疗慢性乙型肝炎(CHB)停药后复发的可能影响因素。方法:选取我院2013年1月-2015年1月期间服用阿德福韦酯治疗并达到停药标准的慢性CHB患者为研究对象。达到停药标准后出现复发患者120例为观察组,同期治疗未复发患者100例为对照组。比较两组患者年龄、性别、吸烟史、饮酒史以及乙肝家族病史,以及实验室检查指标、乙肝血清学指标和病毒学指标等,并比较不良反应发生情况。结果:两组患者的乙肝家族病史和吸烟史比较,差异无统计学意义(P>0.05);观察组患者的男性比例显著高于对照组,46岁以上患者显著多于对照组,饮酒史患者显著多于对照组,差异均有统计学意义(P<0.05)。观察组患者的HBV-DNA显著低于对照组,差异有统计学意义(P<0.05);而实验室检查指标和乙型肝炎E抗原(HBeAg)阳性率与对照组比较,差异无统计学意义(P>0.05)。两组患者在治疗中均未见血磷升高、肌酸激酶、尿素氮、肌酐异常等药品不良反应。结论:患者初始治疗时的HBV-DNA病毒载量、高龄、男性和有饮酒史可能是采用阿德福韦酯治疗慢性CHB停药后复发的影响因素。
OBJECTIVE： To study the possible influential factors of chronic hepatitis B （CHB） recurrent after adefovir ester withdrawal. METHODS： CHB patients receiving adefovir acetate met drug with drawal standard in our hospital during Jan. 2013-Jan. 2015 were selected as the research object. 120 patients suffering from CHB recurrent after drug withdrawal were included in observation group, and 100 patients without CHB recurrent were included in control group. The age, sex, smoking history, drinking history and family history of hepatitis B, biochemical indicators, hepatitis B serology indexes, virology indexes were compared between 2 groups as well as the occurrence of ADR. RESULTS ： There was no statistical significance in family history of hepatitis B and smoking history between 2 groups （P〉0.05） ; the proportion of male in observation group was significantly higher than in control group, patients aged 46 years above of observation group was significantly more than those of control group, patients with drinking history was significantly more than control group, with statistical significance （P〈0.05）. HBV-DNA load of observation group were significantly lower than those of control group, with statistical significance （P〈0.05）. There was no statistical significance in lab indicators and HBeAg positive rate between 2 groups （P〉0.05）. No ADR was found in 2 groups during treatment, such as the elevation of serium inorganic phosphorus, creatine kinase, usea nitrogen and creatinine disorder. CONCLUSIONS： HBV-DNA load, advanced age, female and drinking history may be influential factors of CHB recurrence after drug with- drawal during initial treatment.
出处
《中国药房》
CAS
北大核心
2016年第32期4582-4583,共2页
China Pharmacy
关键词
阿德福韦酯
慢性乙型肝炎
停药
复发
影响因素
Adefovir ester
Chronic hepatitis B
Withdrawal
Recurrence
Influential factor
