摘要
目的探讨肾炎康复片联合氯沙坦钾治疗慢性肾小球肾炎的疗效及对血清白细胞诱素1(LKN-1)、肿瘤坏死因子α(TNF-α)和白细胞介素33(IL-33)的影响。方法选择2011年9月至2014年11月重庆市第五人民医院接诊的慢性肾小球肾炎患者100例。按照随机数字表法分为对照组和观察组,各50例。两组患者均进行常规治疗(预防感染以及注意休息)与抗凝治疗。对照组在常规治疗的基础上给予氯沙坦钾治疗,每次50 mg,每日1次;观察组在对照组的基础上加用肾炎康复片治疗,每次200 mg,每日3次。比较两组患者治疗后的临床疗效,测定治疗前后血清LKN-1、TNF-α和IL-33水平,尿蛋白定量及肾功能改善情况。结果观察组的总有效率显著高于对照组[92.0%(46/50)比68.0%(34/50)],差异有统计学意义(P<0.01);观察组血清中的LKN-1、TNF-α和IL-33均显著低于对照组[(71±20)pmol/L比(132±44)pmol/L,(0.17±0.05)pg/L比(0.40±0.13)pg/L,(68±18)pmol/L比(100±26)pmol/L],差异有统计学意义(P<0.01);观察组尿蛋白显著低于对照组[(1350±210)mg比(1770±270)mg],差异有统计学意义(P<0.05);两组治疗后肾功能指标比较差异无统计学意义(P>0.05)。结论肾炎康复片联合氯沙坦钾治疗慢性肾小球肾炎的效果良好,能够有效降低血清中LKN-1、TNF-α和IL-33水平,值得临床推广。
Objective To explore the effect of nephritis rehabilitation tablet combined with losartan potassium on the serum leukotaxine 1 （ LKN-1 ）, tumor necrosis factor a （TNF-a） and interleukin 33 （ IL-33 ） of patients with chronic glomerulonephritis. Methods Chosen between Sep. 2011 and Nov. 2011,100 cases of chronic glomerulonephritis in Chongqing Fifth People＇s Hospital were included in the study, According to the random number table method they were divided into a control group and an observation group ,50 cases each. Both groups received conventional treatment （anti-infection and rest） and anti-coagulation treatment. The control group was added with losartan potassium ,50 mg per time, 1 time per day;the observation group on the basis of the control group＇s regimen was added with nephritis rehabilitation tablet treatment,200 mg per time,3 times per day. The curative effect,serum LKN-1 ,TNF-a and IL-33 level,proteinuria and renal function improvement of the two groups were compared. Results The total effective rate of the observation group was significantly higher than the control group[ 92. 0% （46/50） vs 68.0% （34/50） ] （P 〈0. 01 ） ;the serum LKN-1 ,TNF-a and IL-33 of the observation group were significantly lower than the control group [ （71 ± 20） pmol/L vs （132 ±44） pmol/L, （0. 17 ±0. 05） pg/L vs （0. 40 ±0. 13） pg/L, （100 ±26） pmol/L vs （68 ± lg） pmol/L] （P 〈 0.01 ） ;the proteinuria of the observation group was significantly lower than the control group[ （1350 ±210） nag vs （1770 ± 270） mg] （P 〈 0. 05 ） ;renal function of the two had no statisti- cally significant difference after treatment（ P 〉 0.05 ）. Conehmion The efficacy of nephritis rehabilitation tablets combined with lasartan potassium for chronic glomerulonephritis is good, which can effectively reduce serum LKN-1, TNF-a and IL-33, thus is worthy of promotion in clinical.
出处
《医学综述》
2016年第21期4296-4298,4305,共4页
Medical Recapitulate
关键词
慢性肾小球肾炎
肾炎康复片
氯沙坦钾
Chronic glomerulonephritis
Nephritis rehabilitation tablets
Losartan potassium
