摘要
目的:探讨非肌层浸润性膀胱癌患者血清和尿液膀胱癌特异性核基质蛋白-(1bladder cancer specific antigen-1,BLCA-1)含量的变化和意义。方法:选取22例非肌层浸润性膀胱癌患者作为实验组,23例前列腺增生患者作为前列腺增生组,21例健康体检者作为正常组。采用ELISA法检测所有受试者血清和尿液样本中BLCA-1的含量,并计算敏感度和特异度。结果:实验组患者尿液BLCA-1的含量明显高于前列腺增生组和正常组(P<0.05);尿液BLCA-1诊断非肌层浸润性膀胱癌的敏感度为59%(13/22),特异度为93%(41/44)。实验组和前列腺增生组患者血清BLCA-1含量明显高于正常组(P<0.05);血清BLCA-1诊断非肌层浸润性膀胱癌的敏感度为86%(19/22),特异度为56%(24/43)。结论:BLCA-1作为非肌层浸润性膀胱癌的新型检测指标,具有较高的敏感度和特异度,值得深入研究。
Objective： To investigate the changes and significance of bladder cancer specific antigen-1 （BLCA-1） content in urine and serum of non muscle-invasive bladder cancer patients. Methods： 22 cases non muscle-invasive bladder cancer patients were taken as experimental group, 23 cases benign prostatic hyperplasia （BHP） patients as BHP group, 21 cases healthy controls as normal group. ELISA was used to detect the BLCA-1 content in urine and serum of all the subjects as well as specificity and sensitivity were calculated. Results： The BLCA-1 content in urine of patients in experimental group was obviously higher than BHP group and normal group （P〈0.05）. The sensitivity and specificity of urine BLCA- 1 content in diagnosis of non muscle-invasive bladder cancer was respectively 59% （13/22） and 93% （41/44）. The BLCA-1 content in serum of patients in experimental group and BHP group was obviously higher than normal group （P〈0.05）. The sensitivity and specificity of serum BLCA-1 content in diagnosis of non muscle-invasive bladder cancer was respectively 86% （19/22） and 56% （24/43）. Conclusions： As a novel marker, BLCA-1 has fairly high sensitivity and specificity in diagnosis of non muscle-invasive bladder cancer.
出处
《承德医学院学报》
2016年第6期459-461,共3页
Journal of Chengde Medical University
