摘要
目的探讨胃炎康胶囊联合铝碳酸镁治疗胆汁反流性胃炎的临床疗效。方法选取2011年3月—2015年3月在子洲县中医院接受治疗的胆汁反流性胃炎患者100例,随机分为对照组(50例)和治疗组(50例)。对照组患者口服铝碳酸镁片,2片/次,3次/d。治疗组在对照组的基础上口服胃炎康胶囊,8粒/次,3次/d。两组患者均连续治疗4周。观察两组的临床疗效,同时比较两组患者治疗前后的胃黏膜充血、水肿和糜烂评分、临床症状总积分、生活质量总积分、胃液胆酸水平、胃酸分泌量以及血清血管活性肠肽(VIP)和白细胞介素-6(IL-6)水平。结果治疗后,对照组和治疗组的总有效率分别为86.00%、98.00%,两组总有效率比较差异有统计学意义(P<0.05)。治疗后,两组患者胃黏膜充血、水肿和糜烂评分显著降低,同组治疗前后差异具有统计学意义(P<0.05);且治疗组这些观察指标的降低程度优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组临床症状和生活质量总积分均显著降低,同组治疗前后差异具有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者液胆酸水平、胃酸分泌量均显著降低,同组治疗前后差异具有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清VIP和IL-6水平均明显降低,同组比较差异具有统计学意义(P<0.05);与对照组相比,治疗组降低的更明显,两组比较差异具有统计学意义(P<0.05)。结论胃炎康胶囊联合铝碳酸镁治疗胆汁反流性胃炎疗效显著,可显著改善患者临床症状,保护胃黏膜,提高患者生活质量,具有一定的临床推广应用价值。
Objective To investigate the clinical effect of Weiyankang Capsules combined with hydrotalcite in treatment of bile reflux gastritis. Methods Patients（100 cases） with bile reflux gastritis in Zizhou County Hospital of TCM from March 2011 to March 2015 were enrolled in this study and divided into control（50 cases） and treatment（50 cases） groups. The patients in the control group were po administered with Hydrotalcite Tablets, 2 tablets/time, three times daily. The patients in the treatment group were po administered with Weiyankang Capsules on the basis of control group, 8 grains/time, three times daily. The patients in two groups were treated for 4 weeks. After treatment, clinical efficacy was evaluated, and scores of congestion, edema and erosion of gastric mucosa, and clinical symptoms total scores, life quality total scores, bile acid content in gastric juice, gastric acid secretion capacity, and serum levels of VIP and IL-6 in two groups before and after treatment were compared. Results After treatment, the efficacies of the control and treatment groups were 86.00% and 98.00%, respectively, and there was significant difference between groups（P〈0.05）. After treatment, the scores of congestion, edema and erosion of gastric mucosa in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, the total scores of clinical symptoms and life quality in two groups were significantly decreased, and the difference was statistically significant in the same group（P〈0.05）. And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups（P〈0.05）. After treatment, bile acid content in gastric juice and gastric acid secretion capacity in two groups were s
出处
《现代药物与临床》
CAS
2016年第10期1542-1546,共5页
Drugs & Clinic
