摘要
目的探讨荧光原位杂交(FISH)技术诊断自然流产绒毛组织染色体异常中的应用价值。方法应用FISH技术对78例孕早期流产绒毛组织进行13/16/18/21/22/X/Y染色体检测分析。结果 78例流产绒毛FISH检测结果中,共发现16例异常,异常核型检出率20.5%,其中发现三倍体4例;16三体4例;21三体5例;22三体3例。结论染色体数目异常是导致孕早期自然流产的主要因素,FISH技术可以快速地检测出流产绒毛组织染色体异常。
Objective：To explore the value of fluorescence in situ hybridization in detecting chromosomal abnormalities of spontaneous abortion. Methods：78 patients who suffered from spontaneous abortion were observed. All of these cases were detected chromosome 13,16,18,21,22,X and Y by FISH. Results：In 78 cases of abortion villi test results were found in 16 patients with abnormal,abnormal karyotype detection rate of 20.5%,which found triploid four cases;4 cases of trisomy 16;5 cases of trisomy 21;3 cases of trisomy 22. Conclusions：Abnormal number of chromosomes are the main factors leading to spontaneous abortion of early pregnancy,FISH technology can quickly detect chromosomal abnormalities of abortion villi.
出处
《中国优生与遗传杂志》
2016年第10期44-45,114,共3页
Chinese Journal of Birth Health & Heredity
关键词
荧光原位杂交
自然流产
染色体异常
孕早期
fluorescence in situ hybridization
spontaneous abortion
chromosomal abnormalities
Early pregnancy
