摘要
目的探讨晚期非小细胞肺癌(NSCLC)患者术后预后的影响因素。方法选取内蒙古第四医院2011年1月—2012年1月收治的晚期NSCLC患者50例,采用自拟调查问卷收集患者的临床资料,包括性别、年龄、体质指数(BMI)、人均月收入、居住地、是否吸烟、是否饮酒、TNM分期、是否发生转移、病理类型、治疗方案、入院时KPS评分、T淋巴细胞亚群及血肌酐(Scr)、尿素氮(BUN)水平。术后采用电话形式对患者进行随访,随访率为100%,随访截止时间为2015-05-01;采用多元Cox回归分析分析晚期NSCLC患者术后预后的影响因素。结果50例患者术后1、2、3年生存率分别为64.0%、36.0%和30.0%,中位生存时间为13.5个月。不同性别、年龄、BMI、病理类型、治疗方案、入院时KPS评分、CD_8^+细胞分数、Scr水平、BUN水平及是否饮酒、发生转移患者累积生存率比较,差异无统计学意义(P>0.05);不同人均月收入、居住地、TNM分期、CD+3细胞分数、CD_4^+细胞分数、CD_4^+/CD_8^+细胞比值及是否吸烟患者累积生存率比较,差异有统计学意义(P<0.05)。多元Cox回归分析结果显示,居住地〔RR=1.724,95%CI(1.194,2.489)〕、吸烟〔RR=2.113,95%CI(1.095,4.077)〕、TNM分期〔RR=1.893,95%CI(1.022,3.506)〕、入院时KPS评分〔RR=2.642,95%CI(1.101,6.339)〕和CD_4^+/CD_8^+细胞比值〔RR=2.012,95%CI(1.121,3.676)〕是晚期NSCLC患者术后预后的影响因素(P<0.05)。结论晚期NSCLC患者术后3年生存率较低,居住地、吸烟、TNM分期、入院时KPS评分及CD_4^+/CD_8^+细胞比值是患者术后预后的影响因素。
Objective To explore the influencing factors of prognosis of postoperative patients with advanced non-small cell lung cancer. Methods A total of 50 patients with advanced non- small cell lung cancer were selected in the Fourth Hospital of Inner Mongolia from January 2011 to January 2012,self- made questionnaire was used to collect their clinical data,including gender,age,BMI,monthly income per person,place of residence,smoking or not,drinking or not,TNM stage,with metastasis or not, pathological types, therapeutic regimens, KPS score at admission, T- lymphocyte subsets, Scr and BUN. Telephone follow- up was carried out after surgery,the follow- up rate was 100%,the deadline was 2015- 05- 01;multivariate Cox regression analysis was used to analyze the influencing factors of prognosis of postoperative patients with advanced non- small cell lung cancer. Results The 1- year,2- year and 3- year survival rate was 64. 0%,36. 0% and 30. 0%,respectively,the median survival time was 13. 5 months. No statistically significant differences of cumulative survival rate was found in patients with different gender, different age, different BMI, different pathological types, different therapeutic regimens,different CD8^＋cell percentage, different Scr, different BUN, with drinking or not, with metastasis or not（ P〉0. 05）; while there were statistically significant differences of cumulative survival rate in patients with different monthly income per person,different places of residence,different KPS scores at admission,different CD＋3cell percentage,different CD4^＋cell percentage,CD4^＋/ CD8^＋cell ratio,with smoking or not（ P〈0. 05）. Multivariate Cox regression analysis results showed that,place of residence 〔RR = 1. 724,95% CI（ 1. 194,2. 489） 〕,smoking 〔RR = 2. 113,95% CI（ 1. 095,4. 077） 〕,TNM stage 〔RR = 1. 893,95% CI（ 1. 022,3. 506） 〕,KPS score at admission 〔RR = 2. 642,95% CI（ 1. 101,6. 339） 〕and CD4^＋/ CD8^＋cell ratio 〔RR = 2. 012,95% CI（ 1. 121,3. 676） 〕were indep
出处
《实用心脑肺血管病杂志》
2016年第10期50-53,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
癌
非小细胞肺
预后
影响因素分析
Carcinoma
non-small-cell lung
Prognosis
Root cause analysis
