摘要
2型糖尿病(T2DM)可增加多种恶性肿瘤的发病风险,如乳腺癌、结肠癌、胰腺癌等,但同时研究发现T2DM可降低前列腺癌(PCa)的发病风险,其影响PCa发病风险的主要因素包括:血糖水平、雄激素水平、前列腺癌特异抗原(PSA)水平、二甲双胍和胰岛素等。此外,近年来研究还发现这些因素同时也能增加PCa患者复发和死亡风险。本文就T2DM上述因素与PCa发病风险和预后关系做一综述。
A large number of epidemiological studies have shown that type 2diabetes mellitus（T2DM）is a risk factor of malignant tumors,such as breast cancer,colorectal cancer,pancreatic cancer,etc.However,epidemiologic evidence provides strong support for the notion that T2 DM can decrease the risk of prostate cancer（PCa）.Hypothesized mechanisms of decreasing PCa risk among T2 DM include blood glucose level,glycosylated hemoglobin（HbA1c）level,androgen level,prostate cancer specific antigen（PSA）level,metformin and insulin,etc.Moreover,T2 DM is associated with the recurrence and poor prognosis of PCa.This review describes the association between T2 DM and PCa from the points of the risk and prognosis of PCa.
出处
《临床泌尿外科杂志》
2016年第10期946-949,共4页
Journal of Clinical Urology
基金
南方医科大学2015年校级大学生创新训练计划项目(编号201512121249)
关键词
前列腺癌
2型糖尿病
发病风险
预后
prostate cancer
type 2 diabetes mellitus
risk of disease
prognosis
