摘要
目的探讨HIV阳性妇女高危型HPV感染及子宫颈细胞学筛查的情况。方法选取首都医科大学附属北京地坛医院2011年6月至2016年5月进行子宫颈病变筛查的58例HIV阳性妇女为观察组，同时选取59例HIV阴性妇女作为对照组，两组均进行子宫颈液基薄层细胞学检查（TCT）及HPV检测。观察两组妇女的TCT异常率、高危型HPV阳性率等，从而分析HIV感染与HPV感染的关系。结果观察组妇女的TCT异常率（91．4％，53／58）明显高于对照组（45．8％，27／59），两组比较，差异有统计学意义（x^2=12．365，P=0．036）；观察组妇女的高危型HPV阳性率（34．5％，20／58）明显高于对照组（16．9％，10／59），两组比较，差异有统计学意义（x^2=10．359，P=0．041）。高危型HPV阳性的HIV阳性妇女，其CD4^＋T淋巴细胞数〉500个／仙1的比例（15．0％，3／20）、CD4^＋/CD8^＋比值〉1的比例（为0）与高危型HPV阴性者[分别为31．6％（12／38）、7．9％（3／38）]存在明显差异，分别比较，差异均有统计学意义（x^2=10．378，P=0．042和）（x^2=9．245，P=0．045）。高危型HPV阳性的HIV阳性妇女，其AIDS不同临床分期的比例与高危型HPV阴性者存在明显差异，分别比较，差异均有统计学意义（P〈0．05）。结论HIV阳性妇女出现TCT异常、感染高危型HPV的比例大，而且HIV阳性妇女感染高危型HPV与CD。’T淋巴细胞数、CD4^＋／CD8^＋比值及AIDS临床分期有一定的关系。
Objective To analysis of high-risk HPV infection and cervical cytologic screening in HIV positive women, and to study the relationship between HIV infection and high-risk HPV infection. Methods From June 2011 to May 2016, 58 cases of HIV positive women in Beijing Ditan Hospital for cervical screening were selected as the experimental group, and 59 cases of HIV negative women were selected as control group, thin-prep cytologic test （TCT） and HPV detection were used in two groups of subjects. The abnormal rate of TCT and the incidence rate of HPV were observed in the two groups, the relationship between HIV infection and HPV infection was analyzed. Results TCT abnormal rate （91.4%, 53/58） of the experimental group was obviously higher than that of the control group （45.8%, 27/59）, with statistically significant （x^2=12.365, P=0.036）. High-risk HPV infection incidence （34.5%, 20/58） of the experimental group was significantly higher than that of the control group （16.9%, 10/59）, with traditional significance （x^2=10.359, P=0.041）. CD4^＋ T lymphocytes and CD4^＋/CD8^＋ ratio of high-risk HPV positive patients had significant difference with high-risk HPV negative patients （x^2=10.378, P=0.042; x^2=9.245, P=0.045）. The proportion of different AIDS clinical stages of high-risk HPV positive patients had obvious difference with high-risk HPV negative patients （P〈0.05）. Conclusion HIV positive women maybe have a large proportion of abnormal TCT and the infection with high-risk HPV, and infection of high-risk HPV in HIV positive women has relationship with CD4^＋ T lymphocytes, CD4^＋/CD8^＋ ratio and AIDS clinical stage.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2016年第10期734-738,共5页
Chinese Journal of Obstetrics and Gynecology
