摘要
目的为明确舒郁降压颗粒对轻中度原发性高血压伴焦虑抑郁障碍的临床疗效。方法将90例符合纳入标准的患者分为舒郁降压颗粒+黛力新(A)组、黛力新+硝苯地平缓释片(Ⅱ)(B)组、舒郁降压颗粒+黛力新+硝苯地平缓释片(C)组,疗程12周,观察治疗前后血压和SAS、SDS评分的变化和达标时间,并记录不良反应。结果 A组、B组、C组降压治疗显效率分别为36.7%、53.3%、66.7%,总有效率分别为96.7%、83.3%、100%,达标时间C组快于A组和B组(P<0.05);SAS评分达标率分别为92.3%、50%、100%,SDS评分达标率分别为100%、65.4%、100%,达标时间3组没有明显差异。结论舒郁降压颗粒治疗轻中度高血压伴焦虑抑郁障碍起到疏肝解郁、滋阴清热、降血压、抗焦虑抑郁的作用。
Objective To figure out the therapeutic effect of Shuyujiangya Particle（ SJP） in treating patients with hypertension with anxiety and depression disorder of mild and moderate degree. Methods Adopting randomized doubleblind double-simulated positive controlled clinical trial design,90 patients were randomly divided into 3 groups,they were treated by SJP ＋ Deanxit（ group A）,Deanxit ＋ Nifedipine sustained release tablets（Ⅱ）（ group B）,SJP ＋ Deanxit ＋Nifedipine sustained release tablets（Ⅱ）（ group C）,30 patients each,respectively for 12 weeks. Changes of blood pressure and SAS/SDS scores in patients before and after treatment were observed and the adverse reactions to the treatment were recorded. Results The markedly effective rate in lowing blood pressure of group A,B and C was 36. 7%,53. 3% and66. 7%,the overall response rate was 96. 7%,83. 3% and 100%,in recovering time group C shorter than group A and B（ P〈0. 05）; the control rate in SAS scores of the 3 groups was 92. 3%,50% and 100%,in SDS scores was 100%,65.4%,100%,the recovering time of the 3 goups do not have significant difference. Conclusion SJP can safely and effectively lower the blood pressure and the scores of anxiety and depression disorder.
出处
《吉林中医药》
2016年第10期995-998,共4页
Jilin Journal of Chinese Medicine
关键词
舒郁降压颗粒
高血压病
焦虑抑郁障碍
中西医结合
SAS
SDS
Shuyu Jiangya particles
hypertension
anxiety and depression disorders
combine traditional Chinese and western medicine
SAS
SDS
