摘要
目的：观察斛柏粉敷脐预防含顺铂的化疗方案所致恶心呕吐的效果。方法选取接受含顺铂（75 mg／m2）化疗方案的患者97例，采用数字表法随机分为观察组（49例）和对照组（48例）。对照组于化疗前30 min 静脉滴注3 mg 格拉司琼止吐；观察组在应用格拉司琼的同时，于化疗前晚用备好的斛柏粉10 g 外敷于神阙穴，每晚换药1次，至化疗结束后次晨停用。观察两组疗效。结果观察组急性呕吐有效率为83．7％，明显高于对照组的60．4％（χ^2＝5．423，P ＝0．019）；观察组迟发性呕吐有效率为85．7％，明显高于对照组的56．3％（χ^2＝8．867，P ＝0．003）；观察组患者食欲明显好于对照组，两组0～Ⅰ度发生率差异有统计学意义（χ^2＝6．469、4．552，P ＝0．011、0．033）；两组Ⅱ～Ⅲ度发生率差异无统计学意义。结论斛柏粉敷脐能有效预防顺铂化疗所致恶心呕吐。
Objective To observe the prevention effect of Hubai powder applied on navel for nausea and vomiting induced by chemotherapy with cisplatin.Methods 97 patients who received chemotherapy with cisplatin （75mg/m2 ）were randomly divided into observation group（n =49）and control group（n =48）.In the control group, 30min before chemotherapy,the patients were treated with intravenous granisetron 3mg as antiemetic;Based on the control group,the observation group were treated with Hubai powder 10g applied on Shenque point in the night before the chemotherapy until the end of the next morning after chemotherapy.The curative effect of the two groups were observed.Results The acute vomiting rate of the observation group was 83.7%,which was significantly higher than that of the control group（60.4%）（χ^2 =5.423,P =0.019）;The delayed vomiting rate of the observation group was 85.7%,which was significantly higher than that of the control group（56.3%）（χ^2 =8.867,P =0.003）;The patient appetite of the observation group was obviously better than that of the control group,0 -Ⅰ degree occurrence rate of the two groups had statistical significance（χ^2 =6.469,4.552,P =0.011,0.033）;Ⅱ -Ⅲ degree occurrence rate of the two groups did＆#39;t have statistical significance.Conclusion Hu Bai powder umbilicus can effectively prevent nausea and vomiting induced by chemotherapy with cisplatin.
作者
姜庥每
张文静
冯曰珍
贾荣娟
Jiang Xiumei Zhang Wenjing Feng Yuezhen Jia Rongjuan(Department of Clinical Oncology , the Central Hospital of Weihai , Weihai , Shandong 264400, China Department of Stomatology , the Central Hospital of Weihai , Weihai , Shandong 264400, China Department of Outpatient, the Central Hospital of Weihai , Weihai , Shandong 264400, China Department of Infection Management, Weihai Municipal lnfectioas Disease Hospital, Weihai, Shandong 264200, China)
出处
《中国基层医药》
CAS
2016年第20期3147-3151,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
斛柏粉
投药
局部
神阙穴
恶心
呕吐
药物疗法
HuBai powder
Administration,topical
Shenque point
Nausea
Vomiting
Drug therapy
