摘要
目的：比较白脉软膏与巴氯芬改善脑卒中患者肌痉挛的疗效。方法将84例伴有肢体痉挛的脑卒中患者按数字表法随机分为白脉软膏组和巴氯芬组，每组42例，白脉软膏组予痉挛肢体外用白脉软膏，巴氯芬组予口服巴氯芬片30～75 mg／d，两组连续用药2周、4周、8周后比较两组患者治疗前后的疗效。结果两组治疗前后的痉挛水平、疼痛水平及日常生活能力差异均有统计学意义，且白脉软膏组治疗后痉挛水平低于巴氯芬组[白脉软膏组在治疗4周、8周后 Ashworth 评分分别为（1．59±0．46）分、（0．89±0．56）分，巴氯芬组在治疗4周、8周后 Ashworth 评分分别为（1．75±0．64）分、（1．45±0．48）分，白脉软膏组 Ashworth 评分明显低于巴氯芬组，差异均有统计学意义（t ＝2．916、3．367，均 P ＜0．05）]，白脉软膏组治疗后疼痛水平低于巴氯芬组[白脉软膏组在治疗2周、4周、8周后 VAS 评分分别为（2．72±0．54）分、（2．02±0．24）分、（1．24±0．12）分，巴氯芬组在治疗2周、4周、8周后 VAS 评分分别为（3．56±0．44）分、（3．15±0．48）分、（2．58±0．26）分，白脉软膏组 VAS 评分明显低于巴氯芬组，差异均有统计学意义（t ＝2．975、3．359、5．416，均P ＜0．05）]，日常生活能力高于巴氯芬组[白脉软膏组在治疗8周后 MBI 评分为（64．46±10．78）分，巴氯芬组在治疗8周后 MBI 评分为（50．74±9．18）分，白脉软膏组 MBI 评分明显高于巴氯芬组，差异有统计学意义（t ＝3．562，P ＜0．05）]。结论白脉软膏在脑卒中患者中的抗痉挛效果优于巴氯芬。
Objective To compare the effects of Baimai ointment and baclofen in stroke patients with spas-ticity.Methods 84 cases accompanied by limb spasticity in stroke patients by digital table were randomly divided into Baimai ointment group and baclofen group,42 cases in each group.The Baimai ointment group were treated with Baimai ointment on the spastic limbs,the baclofen group received oral baclofen tablets 30 -75mg/days for 2 weeks, 4 weeks,8 weeks.The curative effects of the two groups were compared before and after treatment.Results Before and after treatment in the two groups,the levels of spasticity,pain and activities of daily living （ADL）differences were statistically significant and Baimai ointment in the treatment of spasm.After 4 weeks and 8 weeks,the Ashworth score of the Baimai ointment group were （1.59 ±0.46）points,（0.89 ±0.56）points,and those of baclofen group were （1.75 ±0.64）points,（1.45 ±0.48）points,the differences were statistically significant（t values were 2.916, 3.367,all P 〈0.05）.After 2 weeks,4 weeks and 8 weeks,the VAS score of the Baimai ointment group were （2.72 ± 0.54）points,（2.02 ±0.24）points,（1.24 ±0.12）points,and baclofen group were （3.56 ±0.44）points,（3.15 ± 0.48）points,（2.58 ±0.26）points,the differences were statistically significant（t values were 2.975,3.359,5.416, all P 〈0.05）,activities of daily living （ADL）was higher than that of the baclofen group.After 8 weeks,the MBI score of the Baimai ointment group was （64.46 ±10.78）points,and baclofen group was （50.74 ±9.18）points,the difference was statistically significant between the two groups （t values was 3.562,P 〈0.05）.Conclusion Baimai ointment has the better antispasmodic effect than baclofen in patients with stroke.
作者
李亮
陶林花
施明
任芸
尹汉逵
王月丽
孙燕
林斯捷
Li Liang Tao Linhua Shi Ming Ren Yun Yin Hankui Wang Yueli Sun Yan Lin Sijie(Department of Rehabilitation Medicine Center, the Second Hospital of Jiaxing, Jiaxing, Zhejiang 314000, China)
出处
《中国基层医药》
CAS
2016年第20期3076-3079,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省嘉兴市科技局计划项目（2015AY23022）
关键词
白脉软膏
巴氯芬
脑卒中
痉挛
Baimai ointment
Baclofen
Stroke
Spasticity
