摘要
人类免疫缺陷病毒1型（HIV-1）主要通过包膜蛋白刺突感染CD4细胞，刺突由三个二聚体组成，每个二聚体分别由HIV病毒的包膜糖基化蛋白gp120和gp41构成。HIV-1病毒入侵宿主细胞的过程是病毒包膜蛋白gp120／gp41和宿主细胞受体相互作用的结果。HIV-1的包膜蛋白gpl20首先结合于第一受体CD4，然后经历一系列的变构暴露出趋化因子受体（共受体）的结合位点，与共受体CCR5或CXCR4作用，
Acquired immunodeficiency syndrome （AIDS） is mainly caused by human immunodeficiency virus type 1 （HIV-1） infection, and the spread of HIV-1 has brought great threat to human health globally. Therefore, it is the most important and urgent for the control and prevention of the HIV-1 worldwide spread and the development of a safe and effective HIV-1 vaccine. The study of HIV-1 broadly neutralizing g antibodies （bNAbs） has been highly concerned as an important part of vaccine design. In recent years, scien- tists have developed and screened some new generation of bNAbs, such as PGT, VCR01, PG9, PG16, NIH45-46 and BNC etc for HIV-1 vaccine candidates. In this review, we will discuss the recent advances of some potential and wide spectrum HIV-1 bNAbs, as well as summarize the identification methods for these an- tibodies.
作者
王珍
闻婧
洪琛
况轶群
WANG Zhen WEN Jing HONG Chen KUANG Yi-qun(Center for Translational Medicine, Huaihe Clinical Institute, Henan University, Kai feng Henan 475000, Chin)
出处
《中国病毒病杂志》
CAS
2016年第3期236-240,共5页
Chinese Journal of Viral Diseases
基金
国家自然科学基金(81371812
31200130)
河南省高校科技创新团队和创新人才支持计划(17HASTIT049)
