摘要
目的探讨晚期无法手术的乳腺癌患者放射治疗前后癌胚抗原(CEA)、甲胎蛋白(AFP)、糖链抗原125(CA125)、糖链抗原15-3(CA15-3)的变化,探讨CD4^+T细胞对患者放疗效果。方法采用化学发光免疫分析方法检测38例晚期乳腺癌患者和30例健康者血清CEA、AFP、CA125、CA15-3水平;使用流式细胞仪检测外周血CD3^+、CD4^+、CD8^+T百分含量及CD4^+/CD8^+比值。结果 CD4^+T百分含量正常组放疗后CEA、AFP、CA125、CA15-3水平低于放疗前,差异有统计学意义(P<0.05);CD4^+T百分含量异常组放疗后CEA、CA15-3低于放疗前,差异有统计学意义(P<0.05)。结论晚期乳腺癌患者,正常组CD4^+T百分含量放疗前后CEA、AFP、CA125、CA15-3水平有显著差异,该类患者具有放疗临床效果。
Objective The study is aimed to research into the effect of CD4＋T cells on patients with severe advanced breast cancer under radiotherapy that cannot be treated with surgery,by observing the variation of CEA,AFP,CA125 and CA15-3before and after the radiotherapy applied.Methods We identified the CEA,AFP,CA125 and CA15-3densities in blood serum for a group of 38 patients with advanced breast cancer and a group of 30 normal people with chemiluminescence immune assay,and we determined the CD3＋,CD4＋,CD8＋T percentage in peripheral blood and the ratio of CD4＋/CD8＋with flow cytometry.Results The group with normal CD4＋T percentage went through a decreased in CEA,AFP,CA125,CA15-3densities after the radiotherapy,and the variation was significant（P〈0.05）.The group of people with abnormal CD4＋T percentage go through CEA,CA15-3densities decrease after the radiotherapy,and the variation was statistically significant（P〈0.05）.Conclusion For those with advanced breast cancer and cannot be treated with surgery,the influence of radiotherapy on CEA,AFP,CA125,CA15-3densities is significant in the group of patients with CD4＋T percentage,adn has better therapeutic effect.
出处
《国际检验医学杂志》
CAS
2016年第20期2828-2830,共3页
International Journal of Laboratory Medicine
