摘要
目的分析氯吡格雷与阿托伐他汀对短暂性脑缺血发作的临床疗效。方法选取我院在2014年1月至2016年1月收治的80例短暂性脑缺血发作患者,将其随机分为研究组与对照组,每组40例。对照组采用氯吡格雷进行治疗,研究组在对照组的基础上,给予阿托伐他汀进行治疗,比较两组患者的临床疗效及血脂改善情况,如:HDL-C、LDL-C、TC、TG。结果研究组患者与对照组患者的临床总有效率分别为95.00%、82.50%,组间比较差异显著(P<0.05);与治疗前相比,治疗后两组患者的HDL-C、LDL-C、TC、TG均发生变化(P<0.05),与对照组比较,治疗后研究组中TC、TG、LDL-C均明显下降,HDL-C明显上升,差异具有统计学意义(P<0.05)。结论联合应用氯吡格雷与阿托伐他汀对短暂性脑缺血发作进行治疗,具有较好的临床疗效,能改善患者的血脂代谢情况,可供临床推广与应用。
Objective To discuss the treatment effect of clopidogrel combined with atorvastatin in patients with transient cerebral ischemia. Methods Eighty patients with transient cerebral ischemia from January 2014 to January 2016 were collected in our hospital and randomly divided into experiment group and control group. The control group was treated with clopidogrel, and the experiment group received atorvastatin in the foundation treament of control group. The clinical efficacy and the change of blood lipids such as total cholesterol （TC）, triglyceride （TG）, low density lipoprotein cholesterin （LDL-C）, and high density lipoprotein cholesterol （HDL-C） of the two groups were compared. Results The effective rates of the experiment group and control group were 95.00% and 82.50% respectively, the differenc was significant （P〈0.05）. Compared with before treatment, the data of HDL-C, LDL-C, TC, TG between the two groups after treatment were changed and the difference was statistically significant （P〈0.05）. After treatment, the data of TC, TG, LDL-C in the experiment group were obvious lower than those of control group, while the data of HDL-C was obviously increased than that of control group, the differences between groups were statistically significant （P〈0.05）. Conclusion Combination with clopidogrel and atorvastatin can get better clinical outcome in treatment of transient cerebral ischernia, and adjust the blood fat metabolize of patients. Therefore, this therapy should be popularized in clinical medicine.
出处
《临床医学研究与实践》
2016年第22期71-72,共2页
Clinical Research and Practice
