摘要
目前对梅毒免疫学的相关研究已证明,以白细胞介素(IL)-2、干扰素(IFN)γ等为代表的TH1型细胞因子在梅毒早期发挥主要作用,有利于机体对梅毒螺旋体(TP)的清除。随着病程的迁延,TH1型反应受到抑制,TH2型细胞因子介导的免疫应答逐渐占优势,导致梅毒处于潜伏状态。近年发现TH17型细胞因子IL-17在抗梅毒免疫反应中发挥重要作用,而其他TH17相关细胞因子(IL-21,IL-22)在梅毒免疫的作用有待进一步研究。此外,趋化因子配体(CXCL)-13对梅毒感染的作用机制虽不明了,但可能对神经梅毒的诊断有一定的意义。合并HIV感染会影响梅毒的免疫调节作用。
Currently, the study of immunology about syphilis has shown that TH1 cytokines such as interleukin（IL）-2,interferon（INF）-γplay a major role in the early stage of syphilis, which are responsible for the clearance of Treponema pallidum（TP）. With the progression of syphilis, TH1 immune response is suppressed, while TH2 cytokine-mediated immune response gradually become predominant and lead to the latent syphilis. Recently discovered IL-17（TH17 cytokine）can play an important role in the anti-syphilis immune response, while other TH17-related cytokines（IL-21, IL-22）in the role of syphilis immunity need further research. In addition, the chemokine ligand（CXCL）-13 may have a certain significance to the diagnosis of neurosyphilis, while the mechanism of CXCL-13 in syphilis infection is not clear, Syphilis patients with HIV infection can affect the syphilis immune regulation.
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2016年第11期1175-1177,1181,共4页
The Chinese Journal of Dermatovenereology
关键词
细胞因子
梅毒
免疫学
Cytokines
Syphilis
Immunology
