摘要
目的探讨通过放射吸收法(radiographic absorptiometry,RA),获得乌鲁木齐地区人群指骨正常骨峰值及骨质疏松的BMD参考值,为本地区骨质疏松的预防、诊断和治疗提供科学依据。方法本次受检者4828例均剔出骨代谢相关疾病及服用激素类药物史者,用美国Compu Med Osteo Gram-2000骨密度仪测定受检者非优势手的第2、3、4指中节指骨骨密度,按10岁一个年龄组男女各分7组。测试先用岛津XHD-150G 60 X线机对患者非优势手指进行摄片,使用相同摄影条件先后曝光两次。将数据通过美国柯达CR850系统以及Easywork影像工作站(mini PACS)对图像进行数字化处理、传输。最后采用美国Osteo Gram2000骨密度仪进行检测、分析(无片式诊断系统)。结果根据骨密度仪所提供的骨质疏松症诊断标准:本组4828例受检者中,提示骨质量减少(T值介于-1^-2.5之间)者1587例。其中男性548例,占34.5%(548/1587),女性1039例,占65.5%(1039/1587)。诊断骨质疏松症(T值低于-2.5)者1452例。其中,男性384例占26.4%(384/1452)。女性1068例,占73.6%(1068/1452)。本地区受检者骨质疏松患病率为30.0%。男女性骨质丢失率在40岁开始上升,并随着年龄的增长丢失率不断上升。女性44岁(平均44.2±2.6岁)以上开始绝经,绝经后骨量开始快速丢失,当绝经后16~20年时丢失率迅速加快,20年以后缓慢上升。男性骨量减少发生例数与女性有统计学差异(P<0.01),女性骨质疏松发生例数与男性有统计学差异(P<0.01)。乌鲁木齐地区女性绝经年龄与骨量丢失率成正比关系(r=0.9643,P<0.01),绝经0~15年内骨量丢失率平稳上升,16~20年时骨量丢失明显加快,绝经21年以后骨量丢失率变缓,但仍处于上升趋势。结论通过运用放射吸收法对乌鲁木齐地区4828例受检者非优势手指骨骨密度的统计与分析,有效的反映了本地区人群骨矿含量及骨质疏松发病率,并与乌鲁木齐地区DXA与QCT的检测结果相似
Obje ctive To investigate the diagnostic efficacy of radiographic absorptiometry（ RA）,to establish phalanx BMD reference for peak,normal and osteoporosis in the Urumqi region,and to provide a scientific basis for the prevention,diagnosis and treatment of osteoporosis. Me thods 4828 individuals without metabolic bone disease and previous application of steroids were recruited to this study. The Bone mineral density tests of the participants were carried out at the middle phalanx of the second to fourth fingers in non-dominant hand,using an American Compu Med Osteo Gram- 2000 bone sonometer. All of the participants were stratified by ethnicities,of which Han and Wei nationality accounted for a large proportion. Male and female subjects were further divided into 14 groups respectively on the basis of age,with interval of 5 years. Radiograph of non-dominants hands were firstly performed using Dao Jin XHD-150 G 60 X-ray system,and the radiograph was taken twice. The images were then transferred and handled digitally through America Kodak CR850 system and easywork mini PACS and then tested or analyzed by American Osteo Gram2000 bone sonometer（ all of the diagnosis were based on digital image without film）. Re sults Based on bone mineral density instrument’s osteoporosis diagnosis standard： among the 4828 patients,there were 1587 cases of bone quality decrease（ T value between 1- 2. 5）,with 548 cases of men,accounted for 34. 5%（ 548 /1587）,and 1039 cases of women,accounted for65. 5%（ 1039 /1587）. The diagnosis of osteoporosis（ T value less than- 2. 5） was confirmed in 1452 cases. Among them,384 cases of men,accounted for 26. 4%（ 384 /1452）,and 1068 cases of women,accounting for 73. 6%（ 1068 /1452）. The prevalence of osteoporosis in this region was 30. 0%. The rate of bone loss started to rise in both males and females from 40 years of age,and the rate of bone loss increased with advanced age. Women over 44 years of age（ average 44. 2 ± 2. 6 years） began menopause,bone loss occurr
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2016年第10期1277-1282,共6页
Chinese Journal of Osteoporosis
基金
民政部"十一.五"课题(民人教科字(2007)18-1-02)
关键词
骨密度值
放射吸收法
骨矿含量
骨峰值
骨质疏松症
Bone mineral density
Radiographic absorptiometry
Bone mineral content
Peak bone mass
Osteoporosis
