摘要
目的观察采用柔脉法自制中药参芪柔脉合剂对颈动脉粥样硬化病人超敏C反应蛋白(hs-CRP)及颈动脉粥样硬化斑块的影响,并探讨其防治缺血性脑血管病的机制。方法将104例颈动脉粥样硬化病人随机分为两组,对照组50例给予辛伐他汀胶囊口服,试验组54例在对照组基础上给予参芪柔脉合剂。均治疗6个月后,观察两组病人血脂、血清超敏C反应蛋白及颈动脉粥样硬化程度的变化。结果与治疗前比较,两组治疗后颈动脉斑块面积、颈动脉内膜中层厚度、血脂[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)]、血清hs-CRP含量明显降低(P<0.05);与对照组比较,试验组治疗后颈动脉斑块面积、颈动脉内膜中层厚度以及血清hs-CRP含量均显著降低(P<0.05)。结论柔脉法可显著降低颈动脉粥样硬化病人血脂、血清hs-CRP,发挥抗颈动脉粥样硬化作用。
Objective To observe the effects of Shenqi Roumai decoction（ SRD） on blood lipids and high sensitivity C-reactive protein（ hsCRP） in patients with carotid atherosclerosis. Methods One hundred and four patients with carotid atherosclerosis were randomly divided into two groups： control group（n = 50） treated with simvastatin capsules,and treatment group（n = 54） treated with simvastatin capsules plus SRD for 6 months. The change and the signifieanees of carotid intimal-medial thickness（ IMT）,plaques area,blood lipid and hs-CRP were observed in before and after treatment. Results Compared with before treatment,the quantity of plaque diameter of canalis caroticus,the catotid atherosclerosis score,the content of blood lipid and serum hs-CRP were decreased obviously in two groups（P〈0. 05）. Compared with control group,the quantity of plaque diameter of canalis caroticus,the catotid atherosclerosis score,the content of blood lipid and serum hsCRP were decreased obviously in treatment group（P〈0. 05）. Conclusion SRD can reduce the hs-CRP level to inhibit carotid atherosclerosis.
出处
《中西医结合心脑血管病杂志》
2016年第19期2224-2226,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
河北省中医药管理局中医药类科研计划项目(No.2014109)
关键词
颈动脉粥样硬化
参芪柔脉合剂
柔脉法
超敏C反应蛋白
中风
carotid atherosclerosis
Shenqi Roumai decoction
Roumai therapy
high sensitivity C-reactive protein
stroke
