摘要
碳纤维增强聚乳酸(C/PLA)复合材料是较为理想的可降解骨折内固定材料,但由于其降解特性与人体骨骼愈合速度的不匹配,很难达到最佳治疗效果。文中将脉冲电磁场(PEF)引入C/PLA的体外降解过程,并研究了该条件下复合材料的降解特性。结果表明,PEF处理对C/PLA试样的吸水率、质量保持率、弯曲强度和剪切强度均有不同程度的影响;扫描电镜观察发现,PEF处理使界面处的PLA基体出现降解洞穴;差示扫描量热分析说明经不同降解时间的PLA基体的玻璃化转变温度没有明显变化。模型分析表明PEF处理影响降解溶液中正负离子的扩散行为,使得界面处的PLA基体出现局域降解加速区,进而影响C/PLA复合材料的体外降解行为。这一研究将为研究可降解骨折内固定装置的外部辅助治疗器械提供途径。
Carbon reinforced polylactic acid（ C / PLA） composite is a promising degradable implanted material used for internal fracture fixation. However,due to the mismatch between the degradation properties of C / PLA and the bone healing speed in the human body,the best therapeutic effect is thus frequently hard to achieve. This work introduced pulsed electromagnetic field（ PEF） to the process of C / PLA degradation,and the degradation characteristics of C / PLA were studied. The results show that PEF treatment has different influence on the water absorption rate,mass retention,bending strength and shearing strength of C / PLA composite during in vitro degradation; SEM observation indicates that after the PEF treatment,PLA matrix located in the interface exhibits the caves probably resulting from an accelerated degradation; DSC analysis means that the glass transition temperature of PLA matrix degraded for different time doesn＇t change significantly. A proposed mechanism model denotes that PEF treatment affects the diffusion behavior of the positive and negative ions in the degradation solution,and leads an appearance of the degradation accelerating region for the PLA matrix at the interface,and eventually affects the in vitro degradation behavior of C / PLA composite. This work is bound to facilitate the investigation of the external auxiliary treatment instrument for the degradable fracture internal fixation device.
出处
《高分子材料科学与工程》
EI
CAS
CSCD
北大核心
2016年第10期56-60,共5页
Polymer Materials Science & Engineering
基金
国家自然科学基金资助项目(51354001)
辽宁省教育厅重点实验室基础研究项目(LZ2014031)
关键词
碳纤维增强聚乳酸
脉冲电磁场
体外降解
界面降解
正负离子
carbon reinforced polylactic acid
pulsed electromagnetic field
in vitro degradation characteristics
interface degradation
positive and negative ions
