摘要
沙利度胺曾作为一种镇静、催眠药物于19世纪50年代用于妊娠反应等,但是由于其严重的新生儿致畸反应曾一度退出市场。近年来,研究者发现其有免疫调节作用,并用于风湿性疾病的治疗。本文从沙利度胺对风湿性疾病的共同发病机制出发,理解其对系统性红斑狼疮(systemic lupus erythematosus,SLE)、类风湿性关节炎(rheumatoid arthritis,RA)、强直性脊柱炎(anlcylosing spondylitis,AS)、白塞病(Betch′s disease,BD)及皮肌炎(dermatomyositis,DM)的作用机制,并遴选国内外沙利度胺治疗这些疾病临床的研究,认为沙利度胺为这类风湿性疾病的临床用药提供了选择,但需规避其不良反应。
Thalidomide was widely used in pregnancy reaction in 1950 s.However,due to its severe teratogenicity in infants,it was once withdrawed from the market.Recent years,researchers discovered its immunomodulatory function,and put it in use of rheumatologic diseases.This article analyzed the joint pathologic mechanism of systemic lupus erythematosus（SLE）,rheumatoid arthritis（RA）,anlcylosing spondylitis（AS）,Betch′s disease（BD）and dermatomyositis（DM）to illustrate why thalidomide is effective in these diseases.It also reviewed clinical researches on Thalidomide in SLE,RA,AS,BD and DM treatment.We think Thalidomide provides clinicians an option in managing these rheumatology diseases,while its adverse effects should be avoided.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2016年第5期620-624,共5页
Fudan University Journal of Medical Sciences
基金
上海市卫生系统第二批重要疾病联合攻关重点项目(2014ZYJB0010)~~
