摘要
目的:探讨α-D_3对原发性肾病综合征(PNS)患者Pred激素治疗过程中发生骨质疏松的影响。方法:收集我院70例PNS患者,随机分为实验组和对照组。对照组给予泼尼松治疗,实验组在对照组基础上给予α维生素D_3(α-D_3)治疗。观察并比较两组患者治疗前后骨碱性磷酸酶(NBAP)、抗酒石酸酸性磷酸酶(TRACP)、1,25-(OH)_2D_3、前甲状腺素原(iPTH)及骨密度水平的变化情况。结果:与治疗前相比,治疗后两组患者1,25-(OH)_2D_3及骨密度水平均升高,差异具有统计学意义(P<0.05);与治疗前相比,治疗后两组患者NBAP,TRACP及iPTH水平均降低,差异具有统计学意义(P<0.05);与对照组比较,实验组患者治疗后1,25-(OH)_2D_3及骨密度水平较高,差异具有统计学意义(P<0.05),与对照组比较,实验组患者治疗后NBAP,TRACP及iPTH水平较低,差异具有统计学意义(P<0.05)。结论:α-D_3能够降低原发性肾病综合征患者Pred激素治疗期间NBAP,TRACP,iPTH水平,提高1,25-(OH)2D3、骨密度,从而有效预防骨质疏松。
Objective： To investigate the effect of a-D3 on the prevention of osteoporosis in PNS patients during Pred hormone treatment. Methods： 70 patients with PNS were collected and randomly divided into the experiment group and the control group with 35 cases in each group. The patients in the control group were treated with prednisone, while the patients in the experiment group were treated with vitamin D3 （α -D3） besides the control group. Then the bone alkaline phosphatase （NBAP）, tartrate resistant acid phosphatase （TRACP）, 1, 25-（OH） 2 D3, former thyroid hormone （iPTH） and bone density levels of the two groups were observed and compared. Results： Compared with before treatment, the levels of 1, 25 - （OH） 2 D3 and bone density in the two groups increased after treatment, and the differences were statistically significant （P〈0.05）; Compared with before treatment, the levels of NBAP, TRACP and iPTH in the two groups after treatment decreased, and the differences were statistically significant （P〈0.05）; Compared with control group after treatment, the levels of 1, 25-（OH）2 D3 and bone density of the experiment group were higher, and the differences were statistically significant （P〈0. 05; Compared with control group after treatment, the levels ofNBAP, TRACP and iPTH in the experiment group were lower, and the differences were statistically significant （P〈0.05）. Conclusion： α -D3 can decrease the levels ofNBAP, TRACP and iPTH of patients with PNS, and increase the levels of 1, 25- （OH）2 D3 and bone density levels, which would prevent the osteoporosis during Pred hormone treatment.
出处
《现代生物医学进展》
CAS
2016年第30期5854-5857,共4页
Progress in Modern Biomedicine
基金
陕西省科技厅自然科学研究计划项目(2009JM4022)
