摘要
目的:观察注射用丹参多酚酸盐联合西药治疗冠心病不稳定性心绞痛的临床疗效。方法:选取54例冠心病不稳定性心绞痛患者为研究对象,按照随机数字表法分为治疗组和对照组各27例。对照组给予西药治疗,治疗组在对照组用药基础上联合注射用丹参多酚酸盐治疗。比较2组心绞痛、心电图疗效及不良反应发生率,观察2组治疗前后的血液流变学指标(红细胞聚集指数、血浆黏度)和血小板凝聚率的变化。结果:治疗组的心绞痛及心电图疗效总有效率分别为88.89%和85.19%,高于对照组的62.96%和59.26%。2组心绞痛及心电图疗效总有效率比较,差异均有统计学意义(P<0.05)。治疗前,2组血小板凝聚率、血浆黏度及红细胞聚集指数比较,差异均无统计学意义(P>0.05)。治疗后,2组血小板凝聚率、血浆黏度及红细胞聚集指数均较治疗前改善,差异均有统计学意义(P<0.01);治疗组3项指标的改善情况均优于对照组,差异均有统计学意义(P<0.01)。治疗期间2组均无不良反应发生。结论:注射用丹参多酚酸盐联合西药治疗冠心病不稳定性心绞痛,能有效减轻患者的心绞痛程度,促进心电图恢复,改善血液流变学指标和血小板凝聚率。
Objective： To observe the clinical effect of salvianolate injection combined with western medicine in treating patients with unstable angina pectoris. Methods：Selected 54 cases of patients with unstable angina pectoris as study object,and divided into the treatment group and the control group randomly, 27 cases in each group. The conventional western medicine treatment was given to both groups,and the treatment group received additional treatment of salvianolate injection.Compared clinical effect on stenocardia and electrocardiogram in both groups, observed hemorheology indexes（erythroagglutation index, plasmic viscosity）, platelet aggregates ratio and adverse effect rate in two groups before and after treatment. Results：After treatment,the total effective rate of stenocardia and electrocardiogram in the treatment group were88.89% and 85.19% respectively,which were higher than 62.96% and 59.26% in the control group,the differences being significant（P〈0.05）. Before treatment,compared platelet aggregates ratio,plasmic viscosity and erythro- agglutation index in two groups,there were no significant difference（P〉0.05）. After treatment,platelet aggregates ratio,plasmic viscosity and erythro- agglutation index in two groups were all improved（P〈0.01 compared with before treatment）. The improvement in the treatment group was better than that in the control group（P 〈0.01）. There was no adverse reaction in both groups during treatment. Conclusion： The treatment of salvianolate injection combined with western medicine for patients with unstable angina pectoris can relieve stenocardia of patients effectively, promote electrocardiogram recovery, and improve hemorheology indexes and platelet aggregates ratio.
出处
《新中医》
CAS
2016年第10期16-18,共3页
New Chinese Medicine
关键词
冠心病
不稳定性心绞痛
心血瘀阻型
注射用丹参多酚酸盐
血液流变学
Coronary heart disease
Unstable angina pectoris
Type of heart blood stasis
Salvianolate injection
Hemorheology
