摘要
帕金森病(PD)是一种进展性神经变性病,以静止性震颤、肌强直、运动缓慢和姿势异常等运动症状为特征,临床主要通过增加多巴胺(DA)浓度或直接刺激DA受体来改善。PD一旦确诊,应尽快开始治疗,晚期则需在症状波动和运动障碍之间平衡,今后还应加强PD的危险因素筛查及预防。本文综述PD运动症状药物治疗的相关问题。
Parkinson＇s disease （PD） is a progressive neurodegenerative disease characterized by motor symptoms such as tremor, rigidity, bradykinesia and postural instability, and it can be effectively controlled by the drugs, which increase dopamine concentration or directly stimulate dopamine receptor. The PD patients should receive the treatment as soon as the diagnosis has been made. The therapeutic goal of advanced PD needs to be taken balanced between motor fluctuations and dyskinesia. The review describes the drug therapy of motor svmotoms in PD natients.
作者
王宇卉
WANG Yu-hui(Department of Neurology, Shanghai Punan Hospital of Pudong New District, Shanghai 200125, China)
出处
《世界临床药物》
CAS
2016年第10期649-656,共8页
World Clinical Drug
关键词
帕金森病(PD)
运动症状
药物治疗
症状波动
运动障碍
Parkinson＇s disease （PD）
motor symptom
pharmacological treatment
motor fluctuation
dyskinesia
