摘要
肌少症是一种与增龄相关的骨骼肌质量下降，伴有骨骼肌力量和（或）功能下降的老年综合征，可发展为衰弱症，并增加跌倒、失能和死亡的风险。除慢病管控以外，越来越多的证据表明，合理的营养干预，联合规律运动是肌少症的重要防治手段。近年来观察到，补充β-羟基-β-甲基丁酸（β-hydroxy-β-methylbutyrate，HMB），一种被广泛用于健身者或者运动员的亮氨酸代谢产物，对于肌少症具有预防与治疗作用。现总结HMB对肌肉质量、力量与功能的影响的相关临床试验，多数结果显示补充HMB对增加肌肉质量及力量是安全、有效的，多数研究推荐为补充HMB3g／d。然而并不是所有研究的结论都一致。
Sarcopenia is a geriatric syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength with low muscle function. Sarcopenia is correlated with decreased physical function and quality of life, and with increased mortality in the elderly. In addition to managing those chronic diseases,proper nutrition combined with a regular exercise program were indispensable for the prevention and treatment of sarcopenia. It has been observed that heta-hydroxy-beta- methylbutyrate （HMB）, a leucine metabolite, has been extensively used among bodybuilders and strength/power athletes. It may play an important role in prevention and treatment o{ sarcopenia in the elderly. This review summarized those studies indicating an increase in lean mass and strength in the elderly when using HMB. Most researchers seem to agree that the optimal dosage of HMB is 3 g/d. However,not all studies have demonstrated beneficial effects of HMB supplementation.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2016年第10期1135-1138,共4页
Chinese Journal of Geriatrics
