摘要
目的探讨颈动脉斑块形成的相关危险因素及各因素的作用强度，为动脉粥样硬化的一级预防提供理论指导。方法对2009年时仍存活的大庆糖尿病预防研究人群进行观测，包括糖尿病患者395例、非糖尿病对照者209例，常规进行体格及实验室检查，颈动脉超声检测斑块形成的部位及数量。结果颈动脉斑块形成以球部发生率最高（57．5％）；糖尿病组颈动脉斑块发生率明显高于对照组（74．4％比47．4％），尤以多发斑块为著（50．9％比27．8％）；高龄者颈动脉单发及多发斑块的发生风险增加（OR=1．798、3．986）；男性发生颈动脉单发及多发斑块的风险分别是女性的1．599和2．127倍；调整年龄和性别后，收缩压增高是颈动脉斑块形成的最强烈预测因子，收缩性高血压（收缩压≥140mmHg，1mmHg=0．133kPa）者发生单发及多发斑块的风险分别是血压正常者的2．51和13．99倍；收缩性高血压前期（收缩压为120～139mmHg）者发生多发斑块的风险即已增加（OR=6．95）。结论颈动脉斑块形成与高龄、男性、收缩压增高、患有糖尿病、血糖控制水平不佳以及血脂异常显著有关，提示对于后三种可变因素的良好控制有利于动脉硬化疾病的预防。
Objective To evaluate risk factors for carotid plaque formation and the strength of association for each factor, thereby providing theoretical directions for primary prevention of atherosclerosis. Methods The study population came from Da Qing Diabetes Prevention Study （DQDPS） ,including 395 diabetes mellitus（DM）patients and 209 non-diabetes controls who were alive at the last follow-up in 2009. Physical examinations and laboratory tests were performed on each subject,and carotid ultrasound was used to detect the location and quantity of plaque formation. Results The carotid bifurcation had the highest incidence rate（57.5%）of plaque formation in the carotid arteryThe DM group had a much higher incidence rate of plaque formation than the control group（74.4% vs. 47.4%） and in the formation of multiple plaques（50.9% vs. 27.8V0） The risk of single or multiple carotid plaque formation increased with advancing age（OR= 1. 798 or 3. 986） ;The incidence rates for single and multiple carotid plaque formation in males were 1. 599 and 2. 127 times those in females,respectively;After adjustment for age and gender, the strongest predictor for carotid plaque formation was increased systolic blood pressure（SBP）;The risk rates of single and multiple carotid plaque formation for participants with high systolic pressure（SBP^140 mmHg, 1 mmHg= 0. 133 kPa）were 2.51 and 13.99 times, respectively, those for participants with normal systolic pressure,while participants with systolic pressure in the prehypertension range（SBP 120-139mmHg） showed elevated risk already for multiple plaque formation （OR = 6.95）. Conclusions Older age, male gender,elevated SBP, DM, poor control of blood sugar levels and dyslipidemia are significantly associated with carotid plaque formation, suggesting that good control over the latter three factors is conductive to the prevention of carotid plaque formation.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2016年第10期1075-1078,共4页
Chinese Journal of Geriatrics
基金
中国疾控中心/世界卫生组织合作项目（U58/CCU424123-01-02）
关键词
颈动脉
斑块
危险因素
超声检查
动脉粥样硬化
Carotid arteries
Plaque
Risk factors
Ultrasonography
Atherosclerosis
