摘要
类风湿关节炎(RA)是以关节滑膜炎为主要特征的慢性、侵蚀性自身免疫病,其早期临床症状隐匿且多不典型,如不早期治疗,病情反复发作,最终可导致关节的破坏,可致畸甚至丧失劳动能力,严重影响患者的生活质量。RA的发病机制尚不明确,目前认为抗原抗体反应在其发展过程中起着重要作用,因而寻找特异性及敏感性较高、在RA发病早期即可检测到的自身抗体对于RA的诊断是十分必要的,同时也可用于RA的预后及对RA病情活动度的监测,以便临床医生更好地掌握病情并指导治疗。
Rheumatoid arthritis（RA）is a joint synovial inflammation which is a prominent feature of chronic,erosive autoimmune disease. Early clinical symptoms are occult and atypical. If not for the early treatment,an illness will break out repeatedly,ultimately lead to the destruction of the joints,can be deformed or even lose labor ability,seriously affect the patients quality of life. RA patho？genesis is not clear, the antigen？antibody reaction plays an important role in the process of its development. Autoantibodies with higher specificity and sensitivity detected in the early RA disease for the diagnosis of RA is very necessary,can also be used for RA prognosis and monitoring of RA disease activity.
出处
《沈阳医学院学报》
2016年第5期377-380,共4页
Journal of Shenyang Medical College
