摘要
目的了解广州地区献血人群中免疫球蛋白A(IgA)缺乏频率,评估IgA缺乏个体由抗-IgA抗体引起的过敏性输血反应的发生风险。方法收集广州血液中心2014年10月至2015年1月的3 025份献血者外周静脉血标本,采用IgA含量低于0.05 mg/dl为IgA缺乏的检测标准,使用酶联免疫吸附试验筛查IgA缺乏个体,计算相应的IgA缺乏频率。结果广州地区3 025例献血者中有1例IgA缺乏者,频率为0.03%。广州地区献血人群的IgA缺乏频率低于加拿大、西班牙献血人群,差异有统计学意义(P<0.05)。结论 IgA缺乏在广州地区献血人群中存在一定的分布,为避免IgA缺乏者输注含IgA的成分血而产生的过敏性输血反应,应建立IgA缺乏稀有血型库。
Objective To investigate the distribution of immunoglobulin A（Ig A） deficiency in Guangzhou blood donors and assess the risk of anaphylactic transfusion reaction caused by anti-Ig A antibody in Ig A deficiency individuals.Methods Blood samples of 3 025 blood donors were randomly recruited from Guangzhou blood center. The diagnostic criteria of Ig A deficiency defined as Ig A level below or equal to 0.05 mg / dl was used. Enzyme linked immunosorbent assay was performed to screen Ig A deficiency individuals. The incidence of Ig A deficiency was calculated. Results One donor with Ig A deficiency was screened from 3 025 donors and the frequency of Ig A deficiency was 0.03% in Guangzhou blood donors. The frequency of Ig A deficiency in Guangzhou blood donors was significantly higher compared with those in Canadian and Spanish blood donors（P〈0.05）. Conclusion Ig A deficiency was present in Guangzhou blood donors. Ig A deficiency individuals are at risk of severe anaphylactic transfusion reaction when exposed to Ig A during transfusion. Rare blood bank of Ig A deficiency should be set up to ensure transfusion safety of Ig A deficiency individuals.
出处
《热带医学杂志》
CAS
2016年第9期1191-1193,1197,共4页
Journal of Tropical Medicine
基金
广州市医药卫生科技项目(20141A011065)
广州市血液安全重点实验室(201509010009)
关键词
IgA缺乏
过敏性输血反应
献血者
Immunoglobulin A deficiency
Anaphylactic transfusion reaction
Blood donor
