右美托咪啶对老年食管癌根治术患者术中血气指标及术后认知功能的影响被引量：8

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摘要目的观察右美托咪啶对老年食管癌根治术患者术中血气指标及术后认知功能的影响。方法 100例行食管癌根治术的老年患者依纳入顺序单双号随机分为观察组和对照组,各50例。两组给予相同的麻醉诱导和麻醉维持方法,观察组在麻醉诱导期间泵入右美托咪定,对照组同期则给予生理盐水。观察两组血气指标(术前、术中1h及手术结束时BE、PaO2、PaCO2、pH)和认知功能(采用MMSE评估,时间为:术前及术后4,12,24,48h)的变化。结果 (1)术中1h、手术结束时,两组BE、PaO2、pH较术前均明显下降而PaCO2明显上升(P<0.05),但观察组变化幅度均小于同期对照组,差异有统计学意义(P<0.05)。(2)术后4,12,24,48h,两组MMSE评分明显低于术前(P<0.05),但同期比较观察组高于对照组(P<0.05)。术后72h,两组MMSE评分恢复至术前水平(P>0.05),同期比较差异无统计学差异(P>0.05)。结论右美托咪啶有助于维持老年食管癌根治术术中血气稳定,且能改善术后认知功能。

作者王晖王臻杨瑞

机构地区陕西省人民医院麻醉科

出处《贵州医药》 CAS 2016年第9期934-936,共3页 Guizhou Medical Journal

关键词右美托咪啶食管癌血气指标

分类号 R735.1 [医药卫生—肿瘤]

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参考文献9

1Hao Z,Zhenya S,Lei W.Esophageal-gastric anastomosis in radical resection of esophageal cancer under thoracoscopy combined with laparoscopy[J].J Coll Physicians Surg Pak,2014,24(10):754-756. 被引量：1
2张伟,张加强,孟凡民.右美托咪定联合持续气道正压通气对食管癌根治术老年病人单肺通气时肺组织氧化应激反应及炎性反应的影响[J].中华麻醉学杂志,2014,34(1):5-8. 被引量：50
3吕洁,陈庆,嵇家燕,张见岗,郁万友.右美托咪定对老年患者术后认知功能的影响[J].江苏医药,2015,41(23):2842-2843. 被引量：15
4Hosokawa Y,Kinoshita T,Konishi M,et al.Recurrence patterns of esophagogastric junction adenocarcinoma according to Siewert's classification after radical resection[J].Anticancer Res,2014,34(8):4391-4397. 被引量：1
5付琦,庞志路,韩雪萍.右美托咪定对食管癌根治术单肺通气患者肿瘤坏死因子-α和白细胞介素-6的影响[J].中华实验外科杂志,2012,29(11):2304-2306. 被引量：26
6Runkel N,Walz M,Ketelhut M.Abdominothoracic esophageal resection according to Ivor Lewis with intrathoracic anastomosis:standardized totally minimally invasive technique[J].Chirurg,2015,86(5):468-475. 被引量：1
7Turan A,Dalton JE,Kasuya Y,et al.Correlation between bispectral index,observational sedation scale,and loweresophageal sphincter pressure in volunteers using dexmedetomidine or propofol[J].Med Sci Monit,2012,18(10):593-596. 被引量：1
8许忠玲,徐兴国,崔松勤.盐酸右美托咪定对食管癌根治术患者围术期血糖、β-内啡肽、TNF-α及IL-6表达的影响[J].第二军医大学学报,2010,31(12):1330-1332. 被引量：29
9Zcengiz D,Gunes Y,Ozmete O.Oral melatonin,dexmedetomidine,and midazolam for prevention of postoperative agitation in children[J].J Anesth,2011,25(2):184-188. 被引量：1

二级参考文献27

1陈惠荣,李军,刘永勤,吕浩,赵海涛.全麻复合硬膜外阻滞对上腹部手术病人应激反应的影响[J].临床麻醉学杂志,2005,21(2):95-96. 被引量：79
2柯江维,王建红,伍庆华,宣江雷.海马和性腺轴性激素受体的分布及应激时的变化[J].江西中医学院学报,2005,17(2):69-71. 被引量：5
3马武华,吴一龙,林秋雄.单肺通气时IL-6、IL-8、TNF-α mRNA基因表达和乌司他汀的影响[J].中国病理生理杂志,2007,23(2):271-275. 被引量：12
4Mandel J E, Tanner J W, Lichtenstein G R, Metz D C, Katzka D A, Ginsberg G G,et al. A randomized, controlled, double-blind trial of patient-controlled sedation with propofol/remifentanil versus midazolam/fentanyl for colonoseopy[J]. Anesth Analg, 2008,106: 434-439. 被引量：1
5Tan J A, Ho K M. Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta-analysis [J]. Intensive Care Med, 2010,36 :926-939. 被引量：1
6Mansour A, Fox C A, Akil H, Watson S J. Opioid-receptor mR NA expression in the rat CNS: anatomical and functional implications[J]. Trends Neurosci, 1995,18 : 22-29. 被引量：1
7Cote A L,Zhang P,O'Sullivan J A,Jacobs V L,Clemis C R, Sakaguchi S, et al. Stimulation of the glucocorticoid induced TNF receptor family related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens[J]. J Immunol,2010 Nov 24. [Epub ahead of print]. 被引量：1
8Venn R M, Bryant A, Hall G M, Grounds R M. Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post opera tive patients needing sedation in the intensive care unit[J]. Br J Anaesth, 2001, 86: 650-656. 被引量：1
9Costello N L, Bragdon E E, Light K C, Sigurdsson A, Bunting S, Grewen K, et al. Temporomandibular disorder and optimism: relationships to ischemic pain sensitivity and interleukin-6[J]. Pain,2002,100(1-2) :99-110. 被引量：1
10Wilkins B W, Hesse C, Charkoudian N, Nicholson W T, Svig gum H P, Moyer T P, et al. Autonomic cardiovascular control during a novel pharmacologic alternative to ganglionic blockade [J]. Clin Pharmacol Ther, 2008,83 :692-701. 被引量：1